Table 1 miRNAs that are known to target the MECP2 3'UTR and the reported biological significance for each
From: Regulatory functions and pathological relevance of the MECP2 3′UTR in the central nervous system
microRNA | Biological relevance | Reference |
|---|---|---|
miR-132 | Homeostatic regulation of MeCP2 and BDNF. | Klein et al. (2007) [76] |
Reduction of miR-132 during ischemic-preconditioning contributes to elevated MeCP2 levels in the cortex following ischemic injury. | Lusardi et al. (2010) [94] | |
miR-212 | Differential regulation of MeCP2 and BDNF in response to prolonged cocaine intake. | Im et al. (2010) [79] |
miR-7b | Homeostatic regulation of MeCP2 during postnatal development. | Chen et al. (2014) |
miR-483-5p | Human-specific regulation of MeCP2 expression during fetal development. | Han et al. (2013) [81] |
miR-124a | May attenuate nociception by repressing MeCP2 and, by extension, downstream pro-inflammatory genes. | Kynast et al. (2013) [82] |
miR-22 | MeCP2-targeting during ischemic-preconditioning reduces apoptosis and cardiac fibrosis. | Feng et al. (2014) [84] |
Smooth muscle cell differentiation. | Zhao et al. (2015) [83] | |
miR-511 | Only binds MECP2 3'UTR carrying C > T SNP. Reduces peripheral MeCP2 expression by ~50 % and has implications for aggression. | Tantra et al. (2014) [93] |