TY - JOUR AU - He, Songwei AU - Guo, Yiping AU - Zhang, Yixin AU - Li, Yuan AU - Feng, Chengqian AU - Li, Xiang AU - Lin, Lilong AU - Guo, Lin AU - Wang, Haitao AU - Liu, Chunhua AU - Zheng, Yi AU - Luo, Chuanming AU - Liu, Qiang AU - Wang, Fuhui AU - Sun, Hao AU - Liang, Lining AU - Li, Lingyu AU - Su, Huanxing AU - Chen, Jiekai AU - Pei, Duanqing AU - Zheng, Hui PY - 2015 DA - 2015/12/30 TI - Reprogramming somatic cells to cells with neuronal characteristics by defined medium both in vitro and in vivo JO - Cell Regeneration SP - 12 VL - 4 IS - 1 AB - Currently, direct conversion from somatic cells to neurons requires virus-mediated delivery of at least one transcriptional factor or a combination of several small-molecule compounds. Delivery of transcriptional factors may affect genome stability, while small-molecule compounds may require more evaluations when applied in vivo. Thus, a defined medium with only conventional growth factors or additives for cell culture is desirable for inducing neuronal trans-differentiation. SN - 2045-9769 UR - https://doi.org/10.1186/s13619-015-0027-6 DO - 10.1186/s13619-015-0027-6 ID - He2015 ER -