Fig. 6

Inhibition of the N-glycosylation pathway enhances regeneration of the lateral line axon (a) and caudal fin (b). For lateral line axon regeneration, 3 dpf embryos had their lateral line neuron neurectomized and allowed to recover for 24 h. Somite position for the lead edge of the regenerating neuron was then determined. For caudal fin regeneration, WT embryos were amputated at 3 dpf, treated without or with SW for 72 h, and then the area of caudal fin regeneration was measured. Graphs show the mean and s.e.m. A significant difference is detected between the control and 50 μg/ml of swainsonine in axon regeneration (n = 45 for control, n = 33 for SW, p = 0.0015) and fin regeneration (n = 21, p = 0.029)