Fig. 4

Cross-species comparisons of the adult adrenal glands (a) Cross-species correlation analysis of the adult adrenal glands. The fraction of cells in each human cluster was assigned to each mouse cluster based on orthologous genes. The color bar on the right represents the Z-score. Red indicates high correlation; blue and yellow indicate low correlation. b Circos plot showing the similarity of the cell types in adult adrenal glands of humans and mice. The human cluster is marked in red, while the mouse cluster is marked in blue, and different clusters are labeled with different colors. Paired cell types with average AUROC scores greater than 0.9 are connected by lines. c Identification of regulon modules module 1-module 12. This analysis was based on the regulon matrix of the human adrenal gland single-cell data and the mouse adrenal gland single-cell data. The gene regulatory network shows transcription factors (TFs) in different modules and the relationship among 12 regulon modules, along with representative TFs and the associated cell types