TY - JOUR AU - Benavides-Castellanos, Maria Paula AU - Garzón-Orjuela, Nathaly AU - Linero, Itali PY - 2020 DA - 2020/06/02 TI - Effectiveness of mesenchymal stem cell-conditioned medium in bone regeneration in animal and human models: a systematic review and meta-analysis JO - Cell Regeneration SP - 5 VL - 9 IS - 1 AB - Given the limitations of current therapies for the reconstruction of bone defects, regenerative medicine has arisen as a new therapeutic strategy along with mesenchymal stem cells (MSCs), which, because of their osteogenic potential and immunomodulatory properties, have emerged as a promising alternative for the treatment of bone injuries. In vivo studies have demonstrated that MSCs have a positive effect on regeneration due to their secretion of cytokines and growth factors that, when collected in conditioned medium (MSC-CM) and applied to an injured tissue, can modulate and promote the formation of new tissue. SN - 2045-9769 UR - https://doi.org/10.1186/s13619-020-00047-3 DO - 10.1186/s13619-020-00047-3 ID - Benavides-Castellanos2020 ER -