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Table 1 Characteristics of studies

From: Effectiveness of mesenchymal stem cell-conditioned medium in bone regeneration in animal and human models: a systematic review and meta-analysis

Author and yearSpecie/ strainTotal nSource of CM-DosageApplication of MSC-CM
(Ando et al.,2014)Mice / ICRunclearhMSCs − 20 μlDistraction osteogenesis of tibia
Chang et al.,2015)Rats/ Sprague-Dawley21rMSCs-1 mlCircular calvarial bone defect of 5 mm diameter
(Furuta et al.,2016)Mice/ (C57BL/6),CD977hMSCs-100 μlFemur fracture
(Inukai et al.,2013)Dogs / hybrid18hMSCs-300 μlCritical-size, box-type, one-wall intrabony defects (width 4 mm, height 5 mm)
(Katagiri et al.,2013)Rats / Wistar/ST24hMSCs-NRCircular calvarial bone defect of 5 mm diameter
(Katagiri et al.,2015)Rabbits/ (JW/CSK)15hMSCs-NRBilateral cavity in the maxillary sinus (lateral window of 5 × 5 mm)
(Katagiri et al.,2016)Humans8BM-hMSCs-3 mlMaxillary sinus floor elevation (< 5 mm of residual bone)
Katagiri et al.,2017b)Rats /Wistar/ST24hMSCs-NRCircular calvarial bone defect of 5 mm diameter
(Katagiri et al.,2017a)Humans6BM-hMSCs-3 mlMaxillary sinus floor elevation (< 5 mm of residual bone)
(Katagiri et al.,2017c)Rats / Wistar/ST40BM-hMSCs-30 μlCircular calvarial bone defect of 5 mm diameter
(Kawai et al.,2015)Rats /Wistar/STunclearBM-hMSCs-30 μlPeriodontal defect of 1 mm diameter at palatal side of the first molar
(Linero & Chaparro,2014)Rabbits / New Zealand19Ad-hMSCs-16,6 μlBilateral mandibular bone defects of 10 mm diameter
(Ogata et al.,2015)Rats / Wistar/ ST24hMSCs-1 mlExposed bone after tooth extraction in rats with BRONJ
(Osugi et al.,2012)Ratas Wistar/ST40BM-hMSCs-6 mlCircular calvarial bone defect of 5 mm diameter
(Qin et al.,2016)Rats / Sprague Dawley (SD)6BM-hMSCs (Evs) -100 μgCircular calvarial bone defect of 5 mm diameter
(Sanchooli et al.,2017)Rats / Wistar/ST24Ad-rMSCs-NRCircular calvarial bone defect of 5 mm diameter in rats with hypothyroidism
(Tsuchiya et al.,2013)Rats /Sprague- Dawley15BM-rMSCs-1 mg/mlImplant in insertion socket of 1,5 mm diameter created on the femur
(Tsuchiya et al.,2015)Rats / Sprague-Dawley24BM-rMSCs-NRCircular calvarial bone defect of 8 mm diameter
(Wang et al.,2012b)Rats /Sprague–Dawley (SD)unclearhMSCs-100 μlFracture - Bone defect of 2 mm in the middle third of the fibula in rats with diabetes
(Wang et al.,2015)Rats / Sprague-Dawley (SD)8hUCMSCs-10 μgCircular calvarial bone defect of 5 mm diameter
(Xu et al.,2016)Rats / SD24F-hMSCs-100 μlDistraction osteogenesis of tibia transverse osteotomy
  1. hMSCS Human mesenchymal stem cells, rMSCS Rat mesenchymal stem cells, BM Bone marrow, Ad adipose tissue, hUCMSCs Mesenchymal stem cells derived from human umbilical cord, F-hMSCs human fetal mesenchymal stem cells. Evs Extracellular vesicles. NR No report