Effectiveness of mesenchymal stem cell-conditioned medium in bone regeneration in animal and human models: a systematic review and meta-analysis

Benavides-Castellanos, Maria Paula; Garzón-Orjuela, Nathaly; Linero, Itali

doi:10.1186/s13619-020-00047-3

Cell Regeneration

Table 3 Data extraction form

From: Effectiveness of mesenchymal stem cell-conditioned medium in bone regeneration in animal and human models: a systematic review and meta-analysis

General description			pg & fig/table
Title of the study
Authors
Year
ID o DOI
Objective
Protocol and registration
Population and study environment			pg & fig/table
Description of the Population or animal model (species)
Environment (includes location and social context) (human study)
Total population at the beginning of the study Number of clusters (if applicable - Number and type of people per cluster)
Age
Sex
Race / ethnicity
Severity of the disease / co-morbidities
Measurements by subgroup
Methods			pg & fig/table
Study design
Analysis unit (individual, cluster / groups)
Start / end Date
Total duration of the study
Exclusion criteria
Recruitment method (human)
Calculation of sample size
Approval of the ethics committee
Risk assessment of bias for animal and human studies (clinical trials)			pg & fig/table
Domain	Type of risk	Supports
Domain	Low - High - “Unclear”	Supports
Random sequence generation (Animal or human)
Sequence concealment (Animal or human)
Blinding of participants and staff (human)
Blinding of outcome assessor (Animal or human)
Incomplete outcome data (Animal or human)
Selective outcome reporting (Animal or human)
Baseline characteristics between groups (Animal or human)
Random Housing (Animal)
Random outcome assessment (animal)
Blinding of the caregiver or researcher (Animal)
Intervention characteristics
Definition
Administration method
Intervention duration
Comparator group characteristics
Definition
Administration method
Intervention duration
Outcome			pg & fig/table
Outcome name
Definition
How the measurement was applied (interview, email, telephone ...)
Losses (%)
Imputation of lost data
Results (most important)%, mean, standard deviation.
Statistical method used
Other information			pg & fig/table
Conclusions
Financing sources
Note:

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