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Fig. 1 | Cell Regeneration

Fig. 1

From: Erastin-induced ferroptosis is a regulator for the growth and function of human pancreatic islet-like cell clusters

Fig. 1

Susceptibility of ICCs to cytotoxicity in term of LDH release with the treatment of ferroptosis inducer, erastin and inhibitor, ferrostatin-1 (Fer-1). a ICCs were challenged with 20 μM or 50 μM erastin for 24 h. b ICCs were administrated with 1 μM, 5 μM or 10 μM Fer-1 for 24 h. c ICCs were treated with 20 μM erastin in the presence or absence of 5 μM Fer-1 for 24 h. The cell free supernatants were harvested for the measurement of LDH release and the viability of ICCs was expressed in percent of cytotoxicity. The experimental groups were analyzed and compared to the respective non-treatment controls. (n = 5 per group; *p < 0.05, **p < 0.01, ***p < 0.001. All data are expressed as means ± SEM)

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