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Fig. 2 | Cell Regeneration

Fig. 2

From: Erastin-induced ferroptosis is a regulator for the growth and function of human pancreatic islet-like cell clusters

Fig. 2

Decreases in insulin content and expression of differentiation/maturation related genes in ICCs under ferroptosis induction. a Insulin content of ICCs was performed by Ultra-sensitive Insulin Elisa kit after 24 h or 48 h treatment with 20 μM erastin. b Gene expression of differentiation and maturation markers in ICCs (NGN3, NKX2.2, PDX-1 and Insulin) was measured by real-time PCR in relation with the differentiation cocktail derived ICCs. (n = 3 per group; *p < 0.05, **p < 0.01, ***p < 0.001. All data are expressed as means ± SEM)

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