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Fig. 3 | Cell Regeneration

Fig. 3

From: From wound response to repair – lessons from C. elegans

Fig. 3

ESCRT III, SYX-2, and EFF-1 sequential recruitment to regulate membrane repair. C. elegans epidermal membrane repair requires the sequential recruitment of ESCRTIII, SYX-2, and EFF-1 to the wound site. Through exocytosis or endocytosis, pre-existing intracellular vesicles can patch the open wound to carry out membrane repair. As a result of the early wound response, both actin polymerization and Ca2+-regulated ESCRT III signals are required for SYX-2 and EFF-1 recruitment to the wound site

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