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Fig. 5 | Cell Regeneration

Fig. 5

From: RhoA/Rock activation represents a new mechanism for inactivating Wnt/β-catenin signaling in the aging-associated bone loss

Fig. 5

RhoA loss- or gain-of-function affects the bone mass. Tibias from 8-week-old male mice with the genotypes of Col1-Cre (C), Col1-Cre;dnRhoA+/− (Cdn) or Col1-Cre;caRhoA+/− (Cda) were harvested for the following analyses. a, b Representative μCT images and parameters including BV/TV, Tb.Th, Tb.N, and Tb.Sp for the proximal tibias. c, d Representative images of H&E staining and quantification of Ob.N/BS and Ob.S/BS for the proximal tibia sections. e, f Representative images of Trap staining and quantification of Oc.N/BS and Oc.S/BS for the proximal tibia sections. g, h qPCR analyses for Alp, Bsp, Runx2, Lef1, Cyclin D1 (C.D1), and Axin2 mRNA levels in femurs. i, j Dynamic bone histomorphometry and quantification for BFR/BS, MAR, and dLS/BS. Mean ± SEM, *p < 0.05, **p < 0.01, n = 8, Tukey-Kramer multiple comparisons test

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