TY - JOUR AU - Zheng, Lixia AU - Du, Jianyong AU - Wang, Zihao AU - Zhou, Qinchao AU - Zhu, Xiaojun AU - Xiong, Jing-Wei PY - 2021 DA - 2021/04/06 TI - Molecular regulation of myocardial proliferation and regeneration JO - Cell Regeneration SP - 13 VL - 10 IS - 1 AB - Heart regeneration is a fascinating and complex biological process. Decades of intensive studies have revealed a sophisticated molecular network regulating cardiac regeneration in the zebrafish and neonatal mouse heart. Here, we review both the classical and recent literature on the molecular and cellular mechanisms underlying heart regeneration, with a particular focus on how injury triggers the cell-cycle re-entry of quiescent cardiomyocytes to replenish their massive loss after myocardial infarction or ventricular resection. We highlight several important signaling pathways for cardiomyocyte proliferation and propose a working model of how these injury-induced signals promote cardiomyocyte proliferation. Thus, this concise review provides up-to-date research progresses on heart regeneration for investigators in the field of regeneration biology. SN - 2045-9769 UR - https://doi.org/10.1186/s13619-021-00075-7 DO - 10.1186/s13619-021-00075-7 ID - Zheng2021 ER -