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Cell Regeneration
Fig. 1 | Cell Regeneration

Fig. 1

From: Forkhead box family transcription factors as versatile regulators for cellular reprogramming to pluripotency

Fig. 1

FoxD3, FoxD4 and FoxG1 replace Oct4 respectively and induce miPSCs with KS. a Schematics for the process of reprogramming. MEFs were infected with OKS, and then cultured in iCD1 medium. b The effects of Fox transcription factors in OKS mediated reprogramming system. The number of GFP positive iPSC colonies was counted at day 7 after induction from three independent biological assays. *, p < 0.05; **, p < 0.01; ***, p < 0.001. c Oct4-GFP positive colonies were scored at day 4 post infection; OG-MEFs were transduced with OKS and Fox genes; n = 3. **, p < 0.01; ***, p < 0.001. d The proportions of Oct4-GFP positive colonies reflected reprogramming efficiency at day 4 after induction according to flow cytometry analysis. e The number of GFP positive iPSC colonies was counted at day 8 after infection with KS and Fox genes; n = 3

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