Fig. 1

Cell competition between hPSCs and mEpiSCs and overcoming of interspecific competition. a The hPSCs underwent apoptosis in co-culture system of hPSCs and mEpiSCs and did not integrate into the early mouse embryos in vivo. b TP53^KO, P65^KO, MyD88^KO and BCL-2^OE hPSCs, respectively, displayed higher survival rates in the co-culture system with mEpiSCs in vitro and in early mouse embryos in vivo