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Fig. 5 | Cell Regeneration

Fig. 5

From: Activation of the Melanocortin-4 receptor signaling by α-MSH stimulates nerve-dependent mouse digit regeneration

Fig. 5

Digit regeneration in Mc4r+/− mice rescued by α-MSH injection. a Images of wild type (WT) and Mc4r+/− mouse digits at 0, 7, 14, 21 days post amputation (dpa), with PBS or α-MSH injection (1 mg/kg, every other day). Arrowheads indicate amputation levels. Scale bar: 1 mm. b Measurement of area of digit regeneration. Error bars, standard derivation (n = 9 for each group). Students’ t-test was used to compare PBS and α-MSH injected groups against control (Mc4r+/−). There was no significant difference of area of regeneration between Mc4r+/− + PBS and Mc4r+/− groups, between WT and Mc4r+/− + α-MSH groups; There was significant difference between Mc4r+/− + PBS and Mc4r+/− + α-MSH groups, between Mc4r+/− + PBS and Mc4r+/− groups (**)

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