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Fig. 6 | Cell Regeneration

Fig. 6

From: Activation of the Melanocortin-4 receptor signaling by α-MSH stimulates nerve-dependent mouse digit regeneration

Fig. 6

Digit regeneration in denervated hindlimb rescued by α-MSH injection. a Images of adult mouse digits at 0, 7, 14, 21 dpa, with PBS or α-MSH injection (1 mg/kg, every other day, n = 5 for each group), after removal of the sciatic and femoral nerves. b-d GFP expressing nail organ regrown in innervated (b), and α-MSH injected, denervated (d) digit, but is absent in PBS injected, denervated digit (c). e-g Trichrome staining on sections of digit stumps from control (e), PBS injected, hindlimb denervated (f), and α-MSH injected, hindlimb denervated (g) digit. Arrowheads in (a-g) indicate amputation levels. Scale bars: 1 mm in (a), 200 μm in (b-g)

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