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Cell Regeneration
Fig. 7 | Cell Regeneration

Fig. 7

From: Activation of the Melanocortin-4 receptor signaling by α-MSH stimulates nerve-dependent mouse digit regeneration

Fig. 7

Stimulated proximal digit regeneration in neonatal mice by α-MSH. a Images of mouse digits at 0, 7, 14, 21 dpa post proximal digit amputation at PN3, with PBS or α-MSH injection (1 mg/kg, every other day). b Analysis of area of digit regeneration shows the induced regeneration in α-MSH treated group, n = 5 for each group. Error bars: standard derivation, Students’ t-test was used to compare PBS and α-MSH injected groups, and against control. ns, no significant difference between PBS and Control, *** indicates significant difference, p < 0.001, α-MSH injected compared to control group, or PBS group. c Ki67 detection on sections of proximally amputated digits, 21 dpa. Proliferating cells (Ki67) are shown in red. Nuclei counterstained with DAPI are shown in blue. Scale bars: 1 mm in (a), 200 μm in (b, c)

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