Fig. 1
From: Role of PTEN-less in cardiac injury, hypertrophy and regeneration
Biological processes regulated by PTEN after cardiac stress. A. Knockout of Pten with Mck-Cre induces heart hypertrophy in baseline conditions and results in reduced pathological hypertrophy in hearts subjected to aortic banding. B. miR-19a/19b, miR-17-3p, miR-301a, promote cardiomyocytes proliferation after ischemic stress; Cardiac specific knockout Pten induces cardiomyocytes proliferation after myocardial infarction; PTEN specific inhibitor VO-OHpic boosts cardiomyocytes proliferation after myocardial infarction. C. Cardiac inducible knockout of Pten in mice inhibits apoptosis signaling after ischemia/ reperfusion; miR-19a/19b, miR-494, miR-885, VO-OHpic and BpV reduces cardiomyocytes apoptosis after cardiac stress by targeting PTEN. KO, knockout; AB, aortic banding; CMs, cardiomyocytes; VO-OHpic, PTEN specific inhibitor; I/R, ischemia/reperfusion