From: Role of PTEN-less in cardiac injury, hypertrophy and regeneration
Compound | Dose | Object | Effect | Years | Ref. |
---|---|---|---|---|---|
SF1670 | 125-500 nM | Human and mouse neutrophils | Neutrophils treatment with PTEN specific inhibitor SF1670 elevated Ptdlns(3,4,5)-P3 signaling, enhanced the innate immune responses. Mice transfusion with SF1670-treated neutrophils led to augmented bacteria-killing capacity in both peritonitis and bacterial pneumonia | 2011 | (Li et al. 2011) |
SF1670 | 10uM | Human colorectal cancer (CRC) cell lines | Selenite could induce FoxO3a-mediated apoptosis in CRC cells through PTEN-regulated AKT/FoxO3a/Bim signaling pathway, inhibition PTEN by SF1670 abrogated the above changes | 2013 | (Luo et al. 2013) |
SF1670 | 3 nM | Neuronal progenitor striatal cells (NPC) from mouse striatum | Inactivation of PTEN in NPC with SF1670 enhanced the inhibition effect of BDE-49 on mitochondrial respiratory chain electron transport | 2013 | (Napoli et al. 2013) |
SF1670 | 10uM | Human pre-B acute lymphoblastic leukemia (ALL) | Inhibition of PTEN with SF1670 in human pre-B ALL cells induced cell death, with hyperactivation of AKT and activation of the p53 tumor suppressor cell cycle checkpoint | 2016 | (Shojaee et al. 2016) |
VO-OHpic | 500 nM | Human prostate cancer cell lines | Inhibition PTEN with VO-OHpic induces senescence and inhibits tumorigenesis in prostate cancer through enhance p53 translation | 2010 | (Alimonti et al. 2010) |
VO-OHpic | 500 nM | Carcinoid cell line BON | Inhibition of PTEN with VO-OHpic in BON cells result in decreased secretion and synthesis of serotonin,with increased Akt signaling | 2011 | (Silva et al. 2011) |
VO-OHpic | 100 nM | Mouse adrenal chromaffin cells | Abolished the effect of PI3Kδ inhibitor IC87114 on promoting potentiation of Ca2+ − stimulated catecholamine release | 2011 | (Wen et al. 2011) |
VO-OHpic | 500 nM | Breast cancer cells | Abolished the effect of PI3Kδ inhibitor IC87114 on AKT inhibition | 2012 | (Tzenaki et al. 2012) |
VO-OHpic | 0.1-5uM | Mouse ventricular cardiomyocytes | Highly protective against cell death induced by ischemia and reperfusion | 2014 | (Zhu et al. 2014) |
VO-OHpic | 10 μg/kg BW | Mice | Induce cooling-like protection with improved recovery and survival in mouse model of SCA | 2015 | (Li et al. 2015) |
VO-OHpic | 500 nM | Human hepatocellular carcinoma cell lines | Inhibited cell growth and induced senescence in hepatocellular carcinoma (HCC) cells | 2016 | (Augello et al. 2016) |
VO-OHpic | 100uM | Mice superior mesenteric artery | Improved insulin-induced vasodilation in high fat diet-fed mice | 2016 | (da Costa et al. 2016) |
VO-OHpic | 500 nM | Mouse OS tumor cells and human OS cell line | Facilitate tumor growth and expansion in bone | 2017 | (Xi and Chen 2017) |
VO-OHpic | 0.05/2 μg/ml | Rat cardiac myocytes | Improves cardiac myocyte survival after ischemic reperfusion by mediating apoptosis resistance in vitro | 2018 | (Zhang et al. 2018) |
VO-OHpic | 10 μg/kg BW | Mice | Preserve heart function and promote cardiomyocytes proliferation after myocardial infarction | 2020 | (Liang et al. 2020) |