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Table 2 PTEN specific inhibitors

From: Role of PTEN-less in cardiac injury, hypertrophy and regeneration

Compound Dose Object Effect Years Ref.
SF1670 125-500 nM Human and mouse neutrophils Neutrophils treatment with PTEN specific inhibitor SF1670 elevated Ptdlns(3,4,5)-P3 signaling, enhanced the innate immune responses. Mice transfusion with SF1670-treated neutrophils led to augmented bacteria-killing capacity in both peritonitis and bacterial pneumonia 2011 (Li et al. 2011)
SF1670 10uM Human colorectal cancer (CRC) cell lines Selenite could induce FoxO3a-mediated apoptosis in CRC cells through PTEN-regulated AKT/FoxO3a/Bim signaling pathway, inhibition PTEN by SF1670 abrogated the above changes 2013 (Luo et al. 2013)
SF1670 3 nM Neuronal progenitor striatal cells (NPC) from mouse striatum Inactivation of PTEN in NPC with SF1670 enhanced the inhibition effect of BDE-49 on mitochondrial respiratory chain electron transport 2013 (Napoli et al. 2013)
SF1670 10uM Human pre-B acute lymphoblastic leukemia (ALL) Inhibition of PTEN with SF1670 in human pre-B ALL cells induced cell death, with hyperactivation of AKT and activation of the p53 tumor suppressor cell cycle checkpoint 2016 (Shojaee et al. 2016)
VO-OHpic 500 nM Human prostate cancer cell lines Inhibition PTEN with VO-OHpic induces senescence and inhibits tumorigenesis in prostate cancer through enhance p53 translation 2010 (Alimonti et al. 2010)
VO-OHpic 500 nM Carcinoid cell line BON Inhibition of PTEN with VO-OHpic in BON cells result in decreased secretion and synthesis of serotonin,with increased Akt signaling 2011 (Silva et al. 2011)
VO-OHpic 100 nM Mouse adrenal chromaffin cells Abolished the effect of PI3Kδ inhibitor IC87114 on promoting potentiation of Ca2+ − stimulated catecholamine release 2011 (Wen et al. 2011)
VO-OHpic 500 nM Breast cancer cells Abolished the effect of PI3Kδ inhibitor IC87114 on AKT inhibition 2012 (Tzenaki et al. 2012)
VO-OHpic 0.1-5uM Mouse ventricular cardiomyocytes Highly protective against cell death induced by ischemia and reperfusion 2014 (Zhu et al. 2014)
VO-OHpic 10 μg/kg BW Mice Induce cooling-like protection with improved recovery and survival in mouse model of SCA 2015 (Li et al. 2015)
VO-OHpic 500 nM Human hepatocellular carcinoma cell lines Inhibited cell growth and induced senescence in hepatocellular carcinoma (HCC) cells 2016 (Augello et al. 2016)
VO-OHpic 100uM Mice superior mesenteric artery Improved insulin-induced vasodilation in high fat diet-fed mice 2016 (da Costa et al. 2016)
VO-OHpic 500 nM Mouse OS tumor cells and human OS cell line Facilitate tumor growth and expansion in bone 2017 (Xi and Chen 2017)
VO-OHpic 0.05/2 μg/ml Rat cardiac myocytes Improves cardiac myocyte survival after ischemic reperfusion by mediating apoptosis resistance in vitro 2018 (Zhang et al. 2018)
VO-OHpic 10 μg/kg BW Mice Preserve heart function and promote cardiomyocytes proliferation after myocardial infarction 2020 (Liang et al. 2020)