Table 2 Main researches developed in in vivo experiments upon the potential of cell co-cultured in scaffolds to vaginal abnormalities
From: Scaffold strategies combined with mesenchymal stem cells in vaginal construction: a review
Reference | Study model | Regeneration strategy | Cells seeded on scaffolds | Benefits |
|---|---|---|---|---|
De Filippo et al., 2003 | Mice | Engineering vaginal tissues | Vaginal epithelial and smooth muscle cells + PGA | Neovascularization |
De Philippo et al., 2008 | Rabbit | Vaginal replacement | Vaginal epithelial cells and smooth muscle cells + PGA | Neovascularization and appropriate physiological responses |
Raya-Rivera et al., 2014 | Human | Tissue engineered autologous vaginal organs in MRKH syndrome + SIS | Epithelial and smooth muscle cells + SIS | Organized vaginal histology |
Zhu et al., 2013 | Human | MRKH syndrome | No cells; acellular dermal matrix | No complications; anatomic success 100% and normal sexual function |
Panici et al., 2015 | Human | Canal lining in patients with MRKH syndrome | Mucosal vaginal cells; no scaffold | Normal and satisfying sexual intercourse |