Fig. 3
From: Coordination of EZH2 and SOX2 specifies human neural fate decision
EZH2 suppresses meso-endoderm genes while releases neural genes in hESC neural differentiation. a Left panel, heatmap of up- or downregulated genes in wild-type cells at day 8 (WT Day 8) compared with WT cells at day 0 (WT Day 0) neural differentiation. Right panel, GO analysis for up- or downregulated genes in wild-type cells at day 8 (WT Day 8). b Signal densities of H3K27me3-associated genes and EZH2-associated genes in the indicated wild-type (WT) or EZH2-mutant cells at day 0 and day 8 of neural differentiation from ChIP-seq data. c Signal densities for H3K27me3 or EZH2 enrichment from wild-type cells at day 0 and day 8 ChIP-seq data for upregulated genes in wild-type cells at day 8 (WT Day 8). d Signal densities of H3K27me3 and EZH2 enrichment from WT-Day 8 ChIP-seq data for upregulated genes in EZH2-mutant cells at day 8 of neural differentiation. e Genomic views of the H3K27me3 modification and EZH2 enrichment for NPC genes and meso-endoderm genes in wild-type cells at day 0 and day 8 from ChIP-seq data