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Fig. 4 | Cell Regeneration

Fig. 4

From: Coordination of EZH2 and SOX2 specifies human neural fate decision

Fig. 4

Coordination of EZH2 and SOX2 in neural lineage fate decision. a Signal densities heatmap of SOX2-ChIP-seq data indicating regions between WT ESCs and day 8 cells in neural differentiation (WT-Day 8). b Venn diagram for EZH2-binding genes and SOX2-binding genes in WT ESCs. c Signal densities of SOX2 and EZH2 enrichment for EZH2/SOX2 co-binding genes in WT ESCs. d GO analysis for EZH2/SOX2 both binding 678 genes in WT ESCs. e Left panel, Signal densities of SOX2 and EZH2 enrichment from WT-Day 8 ChIP-seq data for EZH2 lost genes, SOX2 lost genes or EZH2/SOX2 keeping genes in wild type cells at day 8 compared with day 0 in neural differentiation (WT-Day 8 and WT-Day 0, respectively). Right panel, GO analysis for EZH2 lost genes, SOX2 lost genes or EZH2/SOX2 keeping genes in WT-Day 8 cells. f RNA expression level in wild-type ESCs and day 8 cells in neural differentiation (WT-Day 8) for EZH2 lost genes, SOX2 lost genes or EZH2/SOX2 keeping genes. g RNA expression level in wild-type and EZH2−/− cells at day 8 in neural differentiation for EZH2-bound and SOX2-bound genes, respectively. h The model for coordination of EZH2 and SOX2 in neural lineage fate decision from hESCs

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