Fig. 4
From: Establishment of porcine and monkey colonic organoids for drug toxicity study
Porcine colonic organoids are more sensitive to drug toxicity. A, B Representative bright-field images (left) and quantitation of cell viability (right) of porcine, monkey and human colonic organoids treated with different concentrations of irinotecan (A) or regorafenib (B) for 4 days. Data are shown as mean ± SD (n = 3 independent experiments). C, D Representative bright-field images (left) and quantitation of cell viability (right) of PCOs in the expansion or differentiation medium treated with irinotecan (C) or regorafenib (D) for 4 days. Data are shown as mean ± SD by two-way ANOVA (n = 3 independent experiments). The significant difference was compared to human colonic organoids. *p < 0.05, ** p < 0.01, ***p < 0.001