Fig. 9From: Development of islet organoids from human induced pluripotent stem cells in a cross-linked collagen scaffoldGlucose stimulated Insulin release in the organoids. Supernatant was collected at 2 h and 24 h after addition of glucose to the medium. The organoids embedded in matrigel (A), GACO gel (B) and collagen (C) also show increased insulin release at all concentrations of added glucose though the response is not seen in 24 h. GSIS was highest at 22 mM of glucoseBack to article page