Fig. 2

Models for hepatocytes renewal. A The streaming liver model proposes that hepatocytes around the portal vein stream to the central vein over time. B The zone 3 model supports that a subset of hepatocytes close to the central vein expand during tissue homeostasis. C The distribution model suggested that hepatocytes distributed throughout the lobule are equally proliferative without preferential proliferation in restricted zone. D The zone 2 model implies that hepatocytes located in the midlobular zone are the main source of new hepatocytes pool