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Fig. 3 | Cell Regeneration

Fig. 3

From: Pathological features of tissues and cell populations during cancer cachexia

Fig. 3

Scheme of some of the most common stem cell populations compromised during cancer cachexia. Release of inflammatory mediators from the tumor alters tissue homeostasis. Resident stem cells appear to modify their behavior when subjected to cachectic conditions. Muscle stem cells appear to have compromised regenerative potential. Adipose stem cells undergo metabolic changes as well as adipocyte shift to a stem-like phenotype. Increased apoptosis in neural stem cells and intestinal stem cells. Hematopoietic stem cells modify their ability to differentiate resulting in the generation of different proportions of immune cells. G-CSF, Granulocyte-colony-stimulating factor; NF-KB, nuclear factor-KB

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