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Cell Regeneration
Fig. 2 | Cell Regeneration

Fig. 2

From: Cross-species single-cell transcriptomic analysis reveals divergence of cell composition and functions in mammalian ileum epithelium

Fig. 2

Conserved cell types and functions of the ileum epithelium across species. A, PCA plot of all cell types for each species (marked by different shapes). Each dot represents a specific cell type from each species. B, Pearson correlation analysis of all cell types of macaque, pig, rat and mouse compared to human. C, D, Alpi staining (C) and Alcian blue staining (D) showing conserved enterocytes and goblet cells across all species. The lower panels show enlargements of the upper panels. Scale bars, 100 μm. E, Expression heatmap of conserved and differential genes and functional enrichments across all species. Genes are divided into 7 modules based on the gene expression pattern. F, Bar plots of scRNA-seq expression (log1p (average expression)) of signature genes in each module as shown in (E)

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