Fig. 2
From: Intestinal cellular heterogeneity and disease development revealed by single-cell technology
Enteroendocrine subtypes and their spatial distribution. A, Main subtypes of enteroendocrine cells and their secreted representative hormones (9 main subtypes in the human intestine are marked by blue). B, Secreted hormones show the spatial difference along the villus-crypt axis. TRPA1, TAC1, and GLP1 are enriched in the crypt, NTS, SCT, and PYY are enriched in the villus, while GIP, CCK, SST, LAPP, and TPH1 show no significant difference. C, Intestinal segmental enrichments of secreted hormones. CCK, GAST, GHRL, and GIP are enriched in the proximal segment, GCG, NTS, PYY, GLP1, NTS, SCGN, UCN3, SST, and REG4 are enriched in the distal segment, while CHGA, CHGB, PCSK1N, SCG2, SCG3, SST, MLN, TPH1, and SCT show no significant difference between the proximal and distal segments