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Fig. 1 | Cell Regeneration

Fig. 1

From: The therapeutic prospects and challenges of human neural stem cells for the treatment of Alzheimer's Disease

Fig. 1

The workflow of postulated subtype- and region-specific cellular replacement therapy for AD. The ideal donor cells will be human induced NSCs (iNSCs) with regional identity that could be generated from adult somatic cells, such as mononuclear cells in peripheral blood, via direct reprogramming. Then, human iNSCs with multiple potential to give rise to subtype-specific neurons could serve as donor cells and will be simultaneously transplanted into brain regions where the same neuron subtypes had been lost or had degenerated. Such subtype- and region-specific transplantations might allow the local and regional replacement of lost neurons, which should consequently lead to the specific and efficient repair of the widely damage neural circuitry AD brain

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