The therapeutic prospects and challenges of human neural stem cells for the treatment of Alzheimer's Disease

Cell Regeneration

Table 1 The summary of representative NSCs cited in this paper

	ESC/iPSC-derived NSCs	iNPCs	Relevant citations
Morphogens/TFs	ESCs, No morphogen		Wang et al., 2006
	ESCs + SHH + RA		Moghadam et al., 2009
	ESCs + SHH		Liu et al., 2013
	iPSC + RA + Noggin		Fujiwara et al., 2013
	ESCs + SHH + BMP9		Yue et al., 2015
		4 YAMANAKA factors	Zhang et al., 2019
Neuronal subtypes	ChAT neurons		Wang et al., 2006; Moghadam et al., 2009
	BFCNs and GABAergic neurons		Liu et al., 2013
	GABAergic neurons		Fujiwara et al., 2013
	BFCNs and Glutamatergic neurons		Yue et al., 2015
		Glutamatergic neurons	Zhang et al., 2019
Host AD mouse	NBM-lesioned mouse/rat		Wang et al., 2006; Moghadam et al., 2009; Liu et al., 2013
Host AD mouse	Transgenic AD mouse	Transgenic AD mouse	Fujiwara et al., 2013; Yue et al., 2015; Zhang et al., 2019
Homogeneity	Heterogenous	Homologous	Liu et al., 2013; Yue et al., 2015; Zhang et al., 2019
Region identity	Hard to be defined	Can be defined	Liu et al., 2013; Yue et al., 2015; Zhang et al., 2019

Abbreviations: NPCs neural stem/progenitor cells, iNPCs induced NPCs, AD Alzheimer’s disease, TF transcription factors, ChAT choline acetyltransferase, BFCNs basal forebrain cholinergic neurons, GABA γ-aminobutyric acid, SHH sonic hedgehog, RA retinoic acid