Fig. 4
From: A mouse model of vitiligo based on endogenous auto-reactive CD8 + T cell targeting skin melanocyte
Lentivirus-mediated shRNA knockdown in skin dermal fibroblasts. a Schematic diagram of lentivirus-mediated shRNA knockdown in the skin dermal fibroblasts. b Representative image of lentivirus-injected area in skin section. Lentivirus infected cells are marked in red by lentivirus expressed H2B-RFP. Scale bar, 50 µm. c-d Whole-mount analysis of distribution pattern of dermal CD8 + T cells and infected fibroblasts (c), and epidermal CD8 + T cells and melanocytes (d) post Stat1-shRNA-containing lentiviruses injection and vitiligo induction. Black dotted line frames indicate the scale region of the tail epidermis. Scale bars, 500 µm