Fig. 1
From: Mitochondrial fragmentation and ROS signaling in wound response and repair
A model of mitochondrial fragmentation and ROS signaling in regulating wound repair. Mitochondria play multiple roles in both single-cellular wound closure and multicellular wound healing. Tissue wound induces an acute elevation of cytosolic Ca2+ through an external influx or internal release, leading to mitochondrial fragmentation dependent on DRP-1 or MIRO-1. As a further response to calcium, the fragmented mitochondria increase mtROS production, promoting actin ring closure in a single cell system. mtROS may also facilitate multicellular wound healing by being involved in angiogenesis and inflammation processes