Skip to main content
Fig. 2 | Cell Regeneration

Fig. 2

From: The dynamics of three-dimensional chromatin organization and phase separation in cell fate transitions and diseases

Fig. 2

Dynamics of phase separation during different cell fate transitions. A Typical phase separation dynamics during early embryogenesis. (1) In C.elegans zygote, P granules are initially distributed in the cytoplasm evenly, and become enriched in the posterior by asymmetric cell division. (2) During C.elegans germline blastomere-to-germ cell transition, Z granule (green) separates from P granule (yellow) near the nucleus. (3) At the onset of ZGA in mice, nucleolus (purple), Cajal bodies (green) and HLB bodies (orange) are assembled at rRNA gene locus, snRNA gene locus and histone gene locus respectively. B Typical phase separation dynamics during cell differentiation. (1) During Drosophila oogenesis, polar granules aggregate at the posterior pole of oocytes initiated by mRNA transport from the nurse cells. (2) During Xenopus/zebrafish oogenesis, the Balbiani body is a large condensate consisting of germ granules and mitochondria near the nucleus, and disperses to vegetal hemisphere during oocyte growth. (3) During mouse spermatogenesis, piP-body locates adjacent to pi-bodies in prospermatogonia firstly, and then fuses with pro-chromatoid body to form mature chromatoid body before round spermatid stage. C During skin barrier formation, keratohyalin granules are gradually formed, and then dissolved due to the dramatic pH decrease

Back to article page