Skip to main content
Fig. 2 | Cell Regeneration

Fig. 2

From: Single-cell transcriptome reveals core cell populations and androgen-RXFP2 axis involved in deer antler full regeneration

Fig. 2

Progenitor, mural, and endothelial cells mainly labeled as proliferative cells. A UMAP to show the distribution of the different cell cycle phases. B Bar plot to show the proportion of different cell cycle phases in different tissue types. C Volcano plot to show the DEGs of bulk RNA-seq between the activated AnLTs (AcAP and AcPP) and the mitotically-quiescent periosteal tissues (DoAP, DoPP and FP). Genes found only in the KEGG cell cycle pathway were labeled. D GSEA plot to show the cell cycle pathways (gene size >= 15 and nominal p-value < 0.005) enriched in the activated AnLTs compared to the mitotically-quiescent tissues. This GSEA enrichment analysis was performed on bulk RNA-seq. E Bar plot to show the proportions of different cell cycle phases of each of the eight cell types in the mixture of all five tissue samples. F Bar plots to show the proportions of different cell cycle phases of each of the three cell types (progenitor cells, endothelial cells, and mural cells) in five individual tissue samples. For mural cells, the proportion of cell cycle phases is shown only in the AcPP, probably because only a few mural cells are resident in the other tissue types. G IHC staining of PCNA in AcPP. Numerous positively stained cells (brown) are shown in the IR; and in the vascular regions of both OR and IR (black arrows). OR, outer sublayer; IR, inner sublayers

Back to article page