Molecular mechanisms of neurite regeneration and repair: insights from C. elegans and Drosophila

Cell Regeneration

Table 3 Regulators during neural regeneration in C. elegans and Drosophila and their mammalian homologues

Invertebrate	Vertebrate	Regulator	References
DLK-1	MAP3K12	Activator	Ghosh-Roy et al. 2012; Hirai et al. 1996; Nix et al. 2011
JNK-1	MAPK10, MAPK8	Activator	Stone et al. 2010
UNC-16	MAPK8IP3, SPAG9	Inhibitor	Kulkarni et al. 2021
EFA-6	PSD3	Inhibitor	Chen et al. 2015
TAC-1	TAC1	Activator	Chen et al. 2015
ZYG-8	DCLK1	Activator	Chen et al. 2015
MLK-1	MAP3K9	Activator	Nix et al. 2011
BRC-2	BRCA2	Activator	Shimizu et al. 2018
ALP-1	LDB3; PDLIM5; PDLIM7	Activator	Shimizu et al. 2018
DAF-2	IGF1R	Inhibitor	Byrne et al. 2014
DAF-16	FOXO	Activator	Byrne et al. 2014
DAF-18	PTEN	Inhibitor	Byrne et al. 2014
LET-363	TOR	Activator	Byrne et al. 2014
MIRO-1	MIRO	Activator	Han et al. 2016
let-7	/	Inhibitor	Zou et al. 2013
LIN-41	TRIM71	Activator	Zou et al. 2013
ALG-1	AGO2	Inhibitor	Zou et al. 2013
miR-87	/	Activator	Kitatani et al. 2020
Ttk69	/	Inhibitor	Kitatani et al. 2020
CED-7	ABCA3	Activator	Basu et al. 2017; Neumann et al. 2015
TTR-52	/	Activator	Neumann et al. 2015
TTR-11	/	Activator	Hisamoto et al. 2018
EFF-1	/	Activator	Basu et al. 2017; Neumann et al. 2015
AFF-1	/	Activator	Oren-Suissa et al. 2017
Mmp2	MMP14; MMP15; MMP16	Inhibitor	DeVault et al. 2018
PXN-2	PXDN	Inhibitor	Gotenstein et al. 2010
AEX-6	RAB27A	Inhibitor	Lin-Moore et al. 2021
SVH-1	TMPRSS15	Activator	Li et al. 2012
SVH-2	TYRO3	Activator	Hisamoto et al. 2016; Li et al. 2012
DDR-2	DDR1; DDR2	Activator	Hisamoto et al. 2016
SHC-1	SHC1	Activator	Hisamoto et al. 2016