Fig. 1From: Physiological and molecular mechanisms of insect appendage regenerationDiagram of appendage regeneration in insects. Following injury or amputation, appendage regeneration in nymphal legs (A and B) or larval imaginal discs (C) proceeds through a generally similar process involving three stages: wound healing, blastema formation, and morphogenesis (regenerative growth, differentiation, and patterning). A In some Blattaria and other orders of insects, when amputation is performed at a site proximal to the femur, a new leg can be regenerated under the exoskeleton after one molt. B In some insects of the order Orthoptera, regeneration mainly occurs at the distal site of the tibia. Four molting cycles are needed for the successful regeneration of missing tissue. C After the surgical amputation of the imaginal leg disc, the smaller fragment from the anterior dorsal quadrant regenerates the remainder of the disc, and a new leg can be regenerated after one molt. Co, coxa; Tr, trochanter; Fe, femur; Ti, tibia; Ta, tarsusBack to article page