Fig. 1From: IL-6/gp130 signaling: a key unlocking regenerationTissue resident macrophages (TRMs) act as sensors of tissue injury. Damage signaling is sensed by and activates TRMs. Activated TRMs crosstalk with tissue cells by releasing IL-6 and its family cytokines to promote parenchymal reprogramming and provoke the proliferation capacity of the cells, leading to regenerative repair through the supplement of lost cells in tissue damage (Taniguchi et al. 2015; Li et al. 2020b; Willis et al. 2020; Li et al. 2023a)Back to article page