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Cell Regeneration
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  1. Given the limitations of current therapies for the reconstruction of bone defects, regenerative medicine has arisen as a new therapeutic strategy along with mesenchymal stem cells (MSCs), which, because of the...

    Authors: Maria Paula Benavides-Castellanos, Nathaly Garzón-Orjuela and Itali Linero
    Citation: Cell Regeneration 2020 9:5
    Content type: Research Published on:

  2. Transposable elements constitute about half of the mammalian genome, and can be divided into two classes: the class I (retrotransposons) and the class II (DNA transposons). A few hundred types of retrotranspos...

    Authors: Jingwen Wang, Junjiu Huang and Guang Shi
    Citation: Cell Regeneration 2020 9:4
    Content type: Review Published on:

  3. Chronic Traumatic Brain Injury (TBI) is one of the common causes of longterm disability worldwide. Cell transplantation has gained attention as a prospective therapeutic option for neurotraumatic disorders lik...

    Authors: Alok K. Sharma, Hemangi M. Sane, Pooja P. Kulkarni, Nandini Gokulchandran, Hema Biju and Prerna B. Badhe
    Citation: Cell Regeneration 2020 9:3
    Content type: Research Published on:

  4. We are using genetics to identify genes specifically involved in hearing regeneration. In a large-scale genetic screening, we identified mgat5a, a gene in the N-glycosylation biosynthesis pathway whose activity n...

    Authors: Wuhong Pei, Sunny C. Huang, Lisha Xu, Kade Pettie, María Laura Ceci, Mario Sánchez, Miguel L. Allende and Shawn M. Burgess
    Citation: Cell Regeneration 2016 5:3
    Content type: Research article Published on:

  5. Increasing evidence indicates that microRNAs (miRNAs), endogenous short non-coding RNAs 19–24 nucleotides in length, play key regulatory roles in various biological events at the post-transcriptional level. Em...

    Authors: Young Jin Lee, Suresh Ramakrishna, Himanshu Chauhan, Won Sun Park, Seok-Ho Hong and Kye-Seong Kim
    Citation: Cell Regeneration 2016 5:2
    Content type: Review Published on:

  7. Currently, direct conversion from somatic cells to neurons requires virus-mediated delivery of at least one transcriptional factor or a combination of several small-molecule compounds. Delivery of transcriptio...

    Authors: Songwei He, Yiping Guo, Yixin Zhang, Yuan Li, Chengqian Feng, Xiang Li, Lilong Lin, Lin Guo, Haitao Wang, Chunhua Liu, Yi Zheng, Chuanming Luo, Qiang Liu, Fuhui Wang, Hao Sun, Lining Liang…
    Citation: Cell Regeneration 2015 4:12
    Content type: Research article Published on:

  8. Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by the loss of motor neurons. Currently, no effective therapy is available to treat ALS, except for Riluzole, which has o...

    Authors: Zhijuan Mao, Suming Zhang and Hong Chen
    Citation: Cell Regeneration 2015 4:11
    Content type: Review Published on:

  11. Tissue-engineered constructs are promising to overcome shortage of organ donors and to reconstruct at least parts of injured or diseased tissues or organs. However, oxygen and nutrient supply are limiting fact...

    Authors: Karoline Pill, Sandra Hofmann, Heinz Redl and Wolfgang Holnthoner
    Citation: Cell Regeneration 2015 4:8
    Content type: Review Published on:

  12. Aging is considered an irreversible biological process and also a major risk factor for a spectrum of geriatric diseases. Advanced age-related decline in physiological functions, such as neurodegeneration, dev...

    Authors: Hoi-Hung Cheung, Duanqing Pei and Wai-Yee Chan
    Citation: Cell Regeneration 2015 4:6
    Content type: Review Published on:

  13. In the past decade, adipose tissue became a highly interesting source of adult stem cells for plastic surgery and regenerative medicine. The isolated stromal vascular fraction (SVF) is a heterogeneous cell pop...

    Authors: Eleni Oberbauer, Carolin Steffenhagen, Christoph Wurzer, Christian Gabriel, Heinz Redl and Susanne Wolbank
    Citation: Cell Regeneration 2015 4:7
    Content type: Methodology Published on:

  15. Hematopoiesis is a progressive process collectively controlled by an elaborate network of transcription factors (TFs). Among these TFs, GATA2 has been implicated to be critical for regulating multiple steps of...

    Authors: Ke Huang, Juan Du, Ning Ma, Jiajun Liu, Pengfei Wu, Xiaoya Dong, Minghui Meng, Wenqian Wang, Xin Chen, Xi Shi, Qianyu Chen, Zhongzhou Yang, Shubin Chen, Jian Zhang, Yuhang Li, Wei Li…
    Citation: Cell Regeneration 2015 4:4
    Content type: Research Published on:

  16. The ability to repair damaged or lost tissues varies significantly among vertebrates. The regenerative ability of the heart is clinically very relevant, because adult teleost fish and amphibians can regenerate...

    Authors: Gunes Ozhan and Gilbert Weidinger
    Citation: Cell Regeneration 2015 4:3
    Content type: Research Published on:

  18. Endothelial cells line the luminal surface of blood vessels and form a barrier between the blood and other tissues of the body. Ets variant 2 (ETV2) is transiently expressed in both zebrafish and mice and is nece...

    Authors: Anne G Lindgren, Matthew B Veldman and Shuo Lin
    Citation: Cell Regeneration 2015 4:1
    Content type: Short report Published on:

  19. Interest in adipose-derived stem cells (ASCs) has increased in recent years due to their multi-linage differentiation capabilities. While much work has been done to optimize the differentiation media, few stud...

    Authors: Mark Ahearne, Joanne Lysaght and Amy P Lynch
    Citation: Cell Regeneration 2014 3:13
    Content type: Short report Published on:

  20. The prokaryotic clustered regularly interspaced short palindromic repeat (CRISPR)-associated system (Cas) is a simple, robust and efficient technique for gene targeting in model organisms such as zebrafish, mi...

    Authors: Quanmei Yan, Quanjun Zhang, Huaqiang Yang, Qingjian Zou, Chengcheng Tang, Nana Fan and Liangxue Lai
    Citation: Cell Regeneration 2014 3:12
    Content type: Research Published on:

  21. The myxovirus resistance gene (Mx1) has a broad spectrum of antiviral activities. It is therefore an interesting candidate gene to improve disease resistance in farm animals. In this study, we report the use o...

    Authors: Quanmei Yan, Huaqiang Yang, Dongshan Yang, Bentian Zhao, Zhen Ouyang, Zhaoming Liu, Nana Fan, Hongsheng Ouyang, Weiwang Gu and Liangxue Lai
    Citation: Cell Regeneration 2014 3:11
    Content type: Research Published on:

  22. SOX transcription factors constitute an attractive target class for intervention with small molecules as they play a prominent role in the field of regenerative biomedicine and cancer biology. However, rationa...

    Authors: Kamesh Narasimhan, Kevin Micoine, Emmanuel Lacôte, Serge Thorimbert, Edwin Cheung, Bernold Hasenknopf and Ralf Jauch
    Citation: Cell Regeneration 2014 3:10
    Content type: Short report Published on:

  23. The transcription factor Oct4 (Pou5f1) is a critical regulator of pluripotency in embryonic and induced pluripotent stem cells. Therefore, Oct4 expression might identify somatic stem cell populations with inheren...

    Authors: Anne Limbourg, Sabine Schnabel, Vladimir J Lozanovski, L Christian Napp, Teng-Cheong Ha, Tobias Maetzig, Johann Bauersachs, Hassan Y Naim, Axel Schambach and Florian P Limbourg
    Citation: Cell Regeneration 2014 3:9
    Content type: Short report Published on:

  25. Oct4 is a key component of the pluripotency regulatory network, and its reciprocal interaction with Cdx2 has been shown to be a determinant of either the self-renewal of embryonic stem cells (ESCs) or their di...

    Authors: Guangming Wu and Hans R Schöler
    Citation: Cell Regeneration 2014 3:7
    Content type: Review Published on:

  26. Native OCT4 protein has the intrinsic ability of crossing cellular membranes to enter cells. This finding could revive efforts to induce pluripotency with proteins replacing nucleic acid-based approaches, and ...

    Authors: Xuecong Wang and Ralf Jauch
    Citation: Cell Regeneration 2014 3:6
    Content type: Commentary Published on:

  28. The conversion of somatic cells into pluripotent stem cells via overexpression of reprogramming factors involves epigenetic remodeling. DNA methylation at a significant proportion of CpG sites in induced pluri...

    Authors: Aline C Planello, Junfeng Ji, Vivek Sharma, Rajat Singhania, Faridah Mbabaali, Fabian Müller, Javier A Alfaro, Christoph Bock, Daniel D De Carvalho and Nizar N Batada
    Citation: Cell Regeneration 2014 3:4
    Content type: Research Published on:

  29. Zinc-finger nucleases and transcription activator-like effector nucleases are novel gene-editing platforms contributing to redefine the boundaries of modern biological research. They are composed of a non-spec...

    Authors: Yu Wang, Nana Fan, Jun Song, Juan Zhong, Xiaogang Guo, Weihua Tian, Quanjun Zhang, Fenggong Cui, Li Li, Philip N Newsome, Jon Frampton, Miguel A Esteban and Liangxue Lai
    Citation: Cell Regeneration 2014 3:3
    Content type: Methodology Published on:

  30. Oct4 is a transcription factor that plays a major role for the preservation of the pluripotent state in embryonic stem cells as well as for efficient reprogramming of somatic cells to induced pluripotent stem ...

    Authors: Eva Harreither, Hanna A Rydberg, Helene L Åmand, Vaibhav Jadhav, Lukas Fliedl, Christina Benda, Miguel A Esteban, Duanqing Pei, Nicole Borth, Regina Grillari-Voglauer, Oliver Hommerding, Frank Edenhofer, Bengt Nordén and Johannes Grillari
    Citation: Cell Regeneration 2014 3:2
    Content type: Research Published on:

  31. Genomic datasets and the tools to analyze them have proliferated at an astonishing rate. However, such tools are often poorly integrated with each other: each program typically produces its own custom output i...

    Authors: Andrew Paul Hutchins, Ralf Jauch, Mateusz Dyla and Diego Miranda-Saavedra
    Citation: Cell Regeneration 2014 3:1
    Content type: Methodology Published on:

  32. Human pluripotent stem cells (hPSCs) are able to self-renew indefinitely and to differentiate into all adult cell types. hPSCs therefore show potential for application to drug screening, disease modelling and ...

    Authors: Jack W Lambshead, Laurence Meagher, Carmel O'Brien and Andrew L Laslett
    Citation: Cell Regeneration 2013 2:7
    Content type: Review Published on:

  33. Tooth is vital not only for a good smile, but also good health. Yet, we lose tooth regularly due to accidents or diseases. An ideal solution to this problem is to regenerate tooth with patients’ own cells. Her...

    Authors: Jinglei Cai, Yanmei Zhang, Pengfei Liu, Shubin Chen, Xuan Wu, Yuhua Sun, Ang Li, Ke Huang, Rongping Luo, Lihui Wang, Ying Liu, Ting Zhou, Shicheng Wei, Guangjin Pan and Duanqing Pei
    Citation: Cell Regeneration 2013 2:6
    Content type: Research Published on:

  34. Zinc-finger nucleases (ZFNs) and transcription activator-like effector nucleases (TALENs) have been successfully used to knock out endogenous genes in stem cell research. However, the deficiencies of current g...

    Authors: Renli Ru, Yongchao Yao, Songlin Yu, Benpeng Yin, Wanwan Xu, Siting Zhao, Li Qin and Xiaoping Chen
    Citation: Cell Regeneration 2013 2:5
    Content type: Methodology Published on:

  37. In Type 1 diabetes, the insulin-producing β-cells within the pancreatic islets of Langerhans are destroyed. We showed previously that immunotherapy with Bacillus Calmette-Guerin (BCG) or complete Freund’s adju...

    Authors: Thomas Hill, Olga Krougly, Enayat Nikoopour, Stacey Bellemore, Edwin Lee-Chan, Lynette A Fouser, David J Hill and Bhagirath Singh
    Citation: Cell Regeneration 2013 2:2
    Content type: Research Published on:

  38. We are now well entering the exciting era of stem cells. Potential stem cell therapy holds great promise for the treatment of many diseases such as stroke, traumatic brain injury, Alzheimer’s disease, Parkinso...

    Authors: Yunying Liu, Ru Yang, Zuping He and Wei-Qiang Gao
    Citation: Cell Regeneration 2013 2:1
    Content type: Review Published on:

  39. Studying embryonic hematopoiesis is complicated by diversity of its locations in the constantly changing anatomy and by the mobility of blood cell precursors. Embryonic hematopoietic progenitors are identified...

    Authors: Igor M Samokhvalov
    Citation: Cell Regeneration 2012 1:9
    Content type: Review Published on:

  41. Pluripotency is depicted by a self-renewing state that can competently differentiate to form the three germ layers. Different stages of early murine development can be captured on a petri dish, delineating a s...

    Authors: Jolene Ooi and Pentao Liu
    Citation: Cell Regeneration 2012 1:7
    Content type: Review Published on:

  43. With their capability to undergo unlimited self-renewal and to differentiate into all cell types in the body, induced pluripotent stem cells (iPSCs), reprogrammed from somatic cells of individual patients with...

    Authors: Zhen-Ning Zhang and Yang Xu
    Citation: Cell Regeneration 2012 1:5
    Content type: Review Published on:

  44. Notch is one of the most important signaling pathways involved in cell fate determination. Activation of the Notch pathway requires the binding of a membrane-bound ligand to the Notch receptor in the adjacent ...

    Authors: Wenguang Yin, Dapeng Liu, Nian Liu, Liangliang Xu, Song Li, Shuo Lin, Xiaodong Shu and Duanqing Pei
    Citation: Cell Regeneration 2012 1:4
    Content type: Research Published on:

  45. Cell-based therapies show promise in repairing cardiac tissue and improving contractile performance following a myocardial infarction. Despite this, ischemia-induced death of transplanted cells remains a major...

    Authors: Curtis C Hughey, Maria P Alfaro, Darrell D Belke, Jeffery N Rottman, Pampee P Young, David H Wasserman and Jane Shearer
    Citation: Cell Regeneration 2012 1:3
    Content type: Short report Published on:

  46. To develop and characterize a novel cell culture method for the generation of undifferentiated and differentiated human mesenchymal stem cell 3D structures, we utilized the RWV system with a gelatin-based scaf...

    Authors: Wolfgang H Cerwinka, Starlette M Sharp, Barbara D Boyan, Haiyen E Zhau, Leland W K Chung and Clayton Yates
    Citation: Cell Regeneration 2012 1:2
    Content type: Research Published on:
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  • ISSN: 2045-9769 (electronic)