Different Pluripotent States in Mouse and Human. (TOP) Distinct pluripotent states derived in vitro from developing mouse embryos or through nuclear reprogramming of somatic cells. Further manipulation through the introduction of genetic factors or modification of growth conditions leads to the attainment of additional pluripotent states, contributing to the complexities of pluripotency. (BOTTOM) Pluripotent states captured in vitro from human blastocysts or nuclear reprogramming of somatic cells. Modelled after pluripotent states during murine development, recent findings suggest the presence of a naïve pluripotent state during human development.