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  1. Information about the dynamic change and post-injury regeneration of cervical epithelium is relatively rare, even though it is tightly related to gynecologic malignancy. Here, using a feeder cell-based culturi...

    Authors: Zixian Zhao, Yujia Wang, Yingchuan Wu, Dandan Li, Ting Zhang, Yu Ma, Xiaoming Teng and Wei Zuo

    Citation: Cell Regeneration 2021 10:36

    Content type: Research article

    Published on:

  2. The evolution of pluripotent stem cell-derived retinal organoids (ROs) has brought remarkable opportunities for developmental studies while also presenting new therapeutic avenues for retinal diseases. With a ...

    Authors: Xiao Zhang, Wen Wang and Zi-Bing Jin

    Citation: Cell Regeneration 2021 10:33

    Content type: Review

    Published on:

  3. Pig and monkey are widely used models for exploration of human diseases and evaluation of drug efficiency and toxicity, but high cost limits their uses. Organoids have been shown to be promising models for dru...

    Authors: Haonan Li, Yalong Wang, Mengxian Zhang, Hong Wang, Along Cui, Jianguo Zhao, Weizhi Ji and Ye-Guang Chen

    Citation: Cell Regeneration 2021 10:32

    Content type: Methodology

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  4. Polycomb repressive complexes (PRCs) are essential in mouse gastrulation and specify neural ectoderm in human embryonic stem cells (hESCs), but the underlying molecular basis remains unclear. Here in this stud...

    Authors: Yuan Zhao, Tianyu Wang, Yanqi Zhang, Liang Shi, Cong Zhang, Jingyuan Zhang, Jiao Yao, Qianyu Chen, Xiaofen Zhong, Yanxing Wei, Yongli Shan and Guangjin Pan

    Citation: Cell Regeneration 2021 10:30

    Content type: Research article

    Published on:

  5. Building human organs in a dish has been a long term goal of researchers in pursue of physiologically relevant models of human disease and for replacement of worn out and diseased organs. The liver has been an...

    Authors: Do Thuy Uyen Ha Lam, Yock Young Dan, Yun-Shen Chan and Huck-Hui Ng

    Citation: Cell Regeneration 2021 10:27

    Content type: Review

    Published on:

  6. Tissue engineering has provided new treatment alternatives for tissue reconstruction. Advances in the tissue engineering field have resulted in mechanical support and biological substitutes to restore, maintai...

    Authors: Nicole Andréa Corbellini Henckes, Dalana Faleiro, Laura Chao Chuang and Elizabeth Obino Cirne-Lima

    Citation: Cell Regeneration 2021 10:26

    Content type: Review

    Published on:

  7. Microanatomy of the vast majority of human organs at birth is characterized by marked differences as compared to adult organs, regarding their architecture and the cell types detectable at histology. In preter...

    Authors: D. Fanni, C. Gerosa, C. Loddo, M. Castagnola, V. Fanos, M. Zaffanello and G. Faa

    Citation: Cell Regeneration 2021 10:22

    Content type: Review

    Published on:

  8. Forkhead box (Fox) transcription factors play important roles in mammalian development and disease. However, their function in mouse somatic cell reprogramming remains unclear. Here, we report that FoxD subfam...

    Authors: Meijun Fu, Huan Chen, Zepo Cai, Yihang Yang, Ziyu Feng, Mengying Zeng, Lijun Chen, Yue Qin, Baomei Cai, Pinghui Zhu, Chunhua Zhou, Shengyong Yu, Jing Guo, Jing Liu, Shangtao Cao and Duanqing Pei

    Citation: Cell Regeneration 2021 10:17

    Content type: Research article

    Published on:

  9. Increasing evidence suggest functional roles of subepithelial mesenchymal niche cells in maintaining intestinal stem cells and in modulating the pathogenesis of various intestinal diseases in mammals. A recent...

    Authors: Guoli Zhu and Rongwen Xi

    Citation: Cell Regeneration 2021 10:24

    Content type: Research Highlight

    Published on:

  10. Ischemic heart disease is one of the main causes of morbidity and mortality in the world. In adult mammalian hearts, most cardiomyocytes are terminally differentiated and have extremely limited capacity of pro...

    Authors: Zhaohui Ouyang and Ke Wei

    Citation: Cell Regeneration 2021 10:14

    Content type: Review

    Published on:

  11. On January 28 in Nature online, Zheng et al. (Nature, 2021 (Online ahead of print)) reported that they developed an ingenious method of interspecies PSC co-culture system in vitro which unfolded interspecific ...

    Authors: Yiren Qin and Duancheng Wen

    Citation: Cell Regeneration 2021 10:18

    Content type: Research Highlight

    Published on:

  12. Expression of Mc4r in peripheral organs indicates it has broader roles in organ homeostasis and regeneration. However, the expression and function of Mc4r in the mouse limb and digit has not been fully investi...

    Authors: Hanqian Xu, Hailin Zhang, Yanqing Fang, Huiran Yang, Ying Chen, Chao Zhang and Gufa Lin

    Citation: Cell Regeneration 2021 10:19

    Content type: Research article

    Published on:

  13. Organoids are three-dimensional self-organizing structures formed by adult tissue stem cells or pluripotent stem cells. They recapitulate cell-cell, cell-niche interactions in tissue development, homeostasis, ...

    Authors: Tiantian Lu, Yiyuan Cao, Peng Zhao, Shengxi Shen and Ying Xi

    Citation: Cell Regeneration 2021 10:21

    Content type: Review

    Published on:

  14. Heart regeneration is a fascinating and complex biological process. Decades of intensive studies have revealed a sophisticated molecular network regulating cardiac regeneration in the zebrafish and neonatal mo...

    Authors: Lixia Zheng, Jianyong Du, Zihao Wang, Qinchao Zhou, Xiaojun Zhu and Jing-Wei Xiong

    Citation: Cell Regeneration 2021 10:13

    Content type: Review

    Published on:

  15. The pluripotent stem cells in planarians, a model for tissue and cellular regeneration, remain further identification. We recently developed a method to enrich piwi-1+ cells in Schmidtea mediterranea, by staining...

    Authors: Kaimeng Niu, Hao Xu, Yuanyi Zhou Xiong, Yun Zhao, Chong Gao, Chris W. Seidel, Xue Pan, Yuqing Ying and Kai Lei

    Citation: Cell Regeneration 2021 10:15

    Content type: Research article

    Published on:

  16. The Wnt/β-catenin signaling pathway appears to be particularly important for bone homeostasis, whereas nuclear accumulation of β-catenin requires the activation of Rac1, a member of the Rho small GTPase family...

    Authors: Wei Shi, Chengyun Xu, Ying Gong, Jirong Wang, Qianlei Ren, Ziyi Yan, Liu Mei, Chao Tang, Xing Ji, Xinhua Hu, Meiyu Qv, Musaddique Hussain, Ling-Hui Zeng and Ximei Wu

    Citation: Cell Regeneration 2021 10:8

    Content type: Research article

    Published on:

  17. Epigenetic modifications, namely non-coding RNAs, DNA methylation, and histone modifications such as methylation, phosphorylation, acetylation, ubiquitylation, and sumoylation play a significant role in brain ...

    Authors: Jiaqi Sun, Junzheng Yang, Xiaoli Miao, Horace H. Loh, Duanqing Pei and Hui Zheng

    Citation: Cell Regeneration 2021 10:7

    Content type: Review

    Published on:

  18. As a result of evolution, the ability to repair wounds allows organisms to combat environment insults. Although the general process of wound healing at the tissue level has been described for decades, the deta...

    Authors: Yicong Ma, Jing Xie, Chandra Sugiarto Wijaya and Suhong Xu

    Citation: Cell Regeneration 2021 10:5

    Content type: Review

    Published on:

  19. The HOX genes are master regulators of embryogenesis that are also involved in hematopoiesis. HOXA9 belongs to a cluster of HOX genes that play extensively studied roles in hematopoiesis and leukemogenesis.

    Authors: Jiahui Zeng, Danying Yi, Wencui Sun, Yuanlin Liu, Jing Chang, Lijiao Zhu, Yonggang Zhang, Xu Pan, Yong Dong, Ya Zhou, Mowen Lai, Guohui Bian, Qiongxiu Zhou, Jiaxin Liu, Bo Chen and Feng Ma

    Citation: Cell Regeneration 2021 10:9

    Content type: Research article

    Published on:

  20. The rapidly self-renewing epithelium in the mammalian intestine is maintained by multipotent intestinal stem cells (ISCs) located at the bottom of the intestinal crypt that are interspersed with Paneth cells i...

    Authors: Guoli Zhu, Jiulong Hu and Rongwen Xi

    Citation: Cell Regeneration 2021 10:1

    Content type: Review

    Published on:

  21. Some lower vertebrates such as zebrafish and axolotl have incredible cardiac regenerative potential while mammals have very limited ones. Comparative studies among species have revealed that cardiomyocyte poly...

    Authors: Jing-Wei Xiong

    Citation: Cell Regeneration 2020 9:23

    Content type: Opinion

    Published on:

  22. Systemic sclerosis is a rare chronic autoimmune disease with extensive microvascular injury, damage of endothelial cells, activation of immune responses, and progression of tissue fibrosis in the skin and vari...

    Authors: Mina Abedi, Sepideh Alavi-Moghadam, Moloud Payab, Parisa Goodarzi, Fereshteh Mohamadi-jahani, Forough Azam Sayahpour, Bagher Larijani and Babak Arjmand

    Citation: Cell Regeneration 2020 9:20

    Content type: Review

    Published on:

  23. Protein quality control (PQC) systems play essential roles in the recognition, refolding and clearance of aberrant proteins, thus ensuring cellular protein homeostasis, or proteostasis. Especially, continued p...

    Authors: Pengze Yan, Jie Ren, Weiqi Zhang, Jing Qu and Guang-Hui Liu

    Citation: Cell Regeneration 2020 9:22

    Content type: Review

    Published on:

  24. Three-dimensional cultured organoids have become a powerful in vitro research tool that preserves genetic, phenotypic and behavioral trait of in vivo organs, which can be established from both pluripotent stem ce...

    Authors: Yaqi Li, Peiyuan Tang, Sanjun Cai, Junjie Peng and Guoqiang Hua

    Citation: Cell Regeneration 2020 9:21

    Content type: Review

    Published on:

  25. Adipose-derived stem cells (ASCs) are considered ideal candidates for both research and cellular therapy due to ease of access, large yield, feasibility, and efficacy in preclinical and clinical studies. Unlik...

    Authors: Nourhan Abu-Shahba, Marwa Mahmoud, Mazen Abdel-Rasheed, Yasmine Darwish, Ahmad AbdelKhaliq, Eman Mohammed, Mahmoud ElHefnawi and Osama Azmy

    Citation: Cell Regeneration 2020 9:18

    Content type: Research article

    Published on:

  26. Retinoic acid (RA) and 2-phospho-L-ascorbic acid trisodium salt (AscPNa) promote the reprogramming of mouse embryonic fibroblasts to induced pluripotent stem cells. In the current studies, the lower abilities ...

    Authors: Mengdan Zhang, Qian Li, Tingting Yang, Fei Meng, Xiaowei Lai, Lining Liang, Changpeng Li, Hao Sun, Jiaqi Sun and Hui Zheng

    Citation: Cell Regeneration 2020 9:17

    Content type: Report

    Published on:

  27. Apparent Young’s modulus (AYM), which reflects the fundamental mechanical property of live cells measured by atomic force microscopy and is determined by substrate stiffness regulated cytoskeletal organization...

    Authors: Anqi Guo, Bingjie Wang, Cheng Lyu, Wenjing Li, Yaozu Wu, Lu Zhu, Ran Bi, Chenyu Huang, Jiao Jiao Li and Yanan Du

    Citation: Cell Regeneration 2020 9:15

    Content type: Research

    Published on:

  28. Clinical applications of cell therapy and tissue regeneration under different conditions need a multiplicity of adult stem cell sources. Up to date, little is available on the comparative isolation, characteri...

    Authors: Abdel Kader A. Zaki, Tariq I. Almundarij and Faten A. M. Abo-Aziza

    Citation: Cell Regeneration 2020 9:13

    Content type: Research

    Published on:

  29. The rapidly developmental RNA-guided CRISPR/Cas system is a powerful tool for RNA and DNA editing in a variety of cells from different species and makes a great contribution to gene function research, disease ...

    Authors: Yanxia Gao, Kexin Gao and Hui Yang

    Citation: Cell Regeneration 2020 9:12

    Content type: Review

    Published on:

    The Correction to this article has been published in Cell Regeneration 2021 10:35

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