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  1. Heart regeneration is a fascinating and complex biological process. Decades of intensive studies have revealed a sophisticated molecular network regulating cardiac regeneration in the zebrafish and neonatal mo...

    Authors: Lixia Zheng, Jianyong Du, Zihao Wang, Qinchao Zhou, Xiaojun Zhu and Jing-Wei Xiong

    Citation: Cell Regeneration 2021 10:13

    Content type: Review

    Published on:

  2. The pluripotent stem cells in planarians, a model for tissue and cellular regeneration, remain further identification. We recently developed a method to enrich piwi-1+ cells in Schmidtea mediterranea, by staining...

    Authors: Kaimeng Niu, Hao Xu, Yuanyi Zhou Xiong, Yun Zhao, Chong Gao, Chris W. Seidel, Xue Pan, Yuqing Ying and Kai Lei

    Citation: Cell Regeneration 2021 10:15

    Content type: Research article

    Published on:

  3. The Wnt/β-catenin signaling pathway appears to be particularly important for bone homeostasis, whereas nuclear accumulation of β-catenin requires the activation of Rac1, a member of the Rho small GTPase family...

    Authors: Wei Shi, Chengyun Xu, Ying Gong, Jirong Wang, Qianlei Ren, Ziyi Yan, Liu Mei, Chao Tang, Xing Ji, Xinhua Hu, Meiyu Qv, Musaddique Hussain, Ling-Hui Zeng and Ximei Wu

    Citation: Cell Regeneration 2021 10:8

    Content type: Research article

    Published on:

  4. Epigenetic modifications, namely non-coding RNAs, DNA methylation, and histone modifications such as methylation, phosphorylation, acetylation, ubiquitylation, and sumoylation play a significant role in brain ...

    Authors: Jiaqi Sun, Junzheng Yang, Xiaoli Miao, Horace H. Loh, Duanqing Pei and Hui Zheng

    Citation: Cell Regeneration 2021 10:7

    Content type: Review

    Published on:

  5. As a result of evolution, the ability to repair wounds allows organisms to combat environment insults. Although the general process of wound healing at the tissue level has been described for decades, the deta...

    Authors: Yicong Ma, Jing Xie, Chandra Sugiarto Wijaya and Suhong Xu

    Citation: Cell Regeneration 2021 10:5

    Content type: Review

    Published on:

  6. The HOX genes are master regulators of embryogenesis that are also involved in hematopoiesis. HOXA9 belongs to a cluster of HOX genes that play extensively studied roles in hematopoiesis and leukemogenesis.

    Authors: Jiahui Zeng, Danying Yi, Wencui Sun, Yuanlin Liu, Jing Chang, Lijiao Zhu, Yonggang Zhang, Xu Pan, Yong Dong, Ya Zhou, Mowen Lai, Guohui Bian, Qiongxiu Zhou, Jiaxin Liu, Bo Chen and Feng Ma

    Citation: Cell Regeneration 2021 10:9

    Content type: Research article

    Published on:

  7. The rapidly self-renewing epithelium in the mammalian intestine is maintained by multipotent intestinal stem cells (ISCs) located at the bottom of the intestinal crypt that are interspersed with Paneth cells i...

    Authors: Guoli Zhu, Jiulong Hu and Rongwen Xi

    Citation: Cell Regeneration 2021 10:1

    Content type: Review

    Published on:

  8. Some lower vertebrates such as zebrafish and axolotl have incredible cardiac regenerative potential while mammals have very limited ones. Comparative studies among species have revealed that cardiomyocyte poly...

    Authors: Jing-Wei Xiong

    Citation: Cell Regeneration 2020 9:23

    Content type: Opinion

    Published on:

  9. Systemic sclerosis is a rare chronic autoimmune disease with extensive microvascular injury, damage of endothelial cells, activation of immune responses, and progression of tissue fibrosis in the skin and vari...

    Authors: Mina Abedi, Sepideh Alavi-Moghadam, Moloud Payab, Parisa Goodarzi, Fereshteh Mohamadi-jahani, Forough Azam Sayahpour, Bagher Larijani and Babak Arjmand

    Citation: Cell Regeneration 2020 9:20

    Content type: Review

    Published on:

  10. Protein quality control (PQC) systems play essential roles in the recognition, refolding and clearance of aberrant proteins, thus ensuring cellular protein homeostasis, or proteostasis. Especially, continued p...

    Authors: Pengze Yan, Jie Ren, Weiqi Zhang, Jing Qu and Guang-Hui Liu

    Citation: Cell Regeneration 2020 9:22

    Content type: Review

    Published on:

  11. Three-dimensional cultured organoids have become a powerful in vitro research tool that preserves genetic, phenotypic and behavioral trait of in vivo organs, which can be established from both pluripotent stem ce...

    Authors: Yaqi Li, Peiyuan Tang, Sanjun Cai, Junjie Peng and Guoqiang Hua

    Citation: Cell Regeneration 2020 9:21

    Content type: Review

    Published on:

  12. Adipose-derived stem cells (ASCs) are considered ideal candidates for both research and cellular therapy due to ease of access, large yield, feasibility, and efficacy in preclinical and clinical studies. Unlik...

    Authors: Nourhan Abu-Shahba, Marwa Mahmoud, Mazen Abdel-Rasheed, Yasmine Darwish, Ahmad AbdelKhaliq, Eman Mohammed, Mahmoud ElHefnawi and Osama Azmy

    Citation: Cell Regeneration 2020 9:18

    Content type: Research article

    Published on:

  13. Retinoic acid (RA) and 2-phospho-L-ascorbic acid trisodium salt (AscPNa) promote the reprogramming of mouse embryonic fibroblasts to induced pluripotent stem cells. In the current studies, the lower abilities ...

    Authors: Mengdan Zhang, Qian Li, Tingting Yang, Fei Meng, Xiaowei Lai, Lining Liang, Changpeng Li, Hao Sun, Jiaqi Sun and Hui Zheng

    Citation: Cell Regeneration 2020 9:17

    Content type: Report

    Published on:

  14. Apparent Young’s modulus (AYM), which reflects the fundamental mechanical property of live cells measured by atomic force microscopy and is determined by substrate stiffness regulated cytoskeletal organization...

    Authors: Anqi Guo, Bingjie Wang, Cheng Lyu, Wenjing Li, Yaozu Wu, Lu Zhu, Ran Bi, Chenyu Huang, Jiao Jiao Li and Yanan Du

    Citation: Cell Regeneration 2020 9:15

    Content type: Research

    Published on:

  15. Clinical applications of cell therapy and tissue regeneration under different conditions need a multiplicity of adult stem cell sources. Up to date, little is available on the comparative isolation, characteri...

    Authors: Abdel Kader A. Zaki, Tariq I. Almundarij and Faten A. M. Abo-Aziza

    Citation: Cell Regeneration 2020 9:13

    Content type: Research

    Published on:

  16. The pathological feature of diabetes, hyperglycemia, is a result of an inadequate number and/or function of insulin producing β cells. Replenishing functional β cells is a strategy to cure the disease. Althoug...

    Authors: Bingyuan Yang, Brittney A. Covington and Wenbiao Chen

    Citation: Cell Regeneration 2020 9:9

    Content type: Review

    Published on:

  17. Recovery of liver mass to a healthy liver donor by compensatory regeneration after partial hepatectomy (PH) is a prerequisite for liver transplantation. Synchronized cell cycle reentry of the existing hepatocy...

    Authors: Feng Chen, Delai Huang, Hui Shi, Ce Gao, Yingchun Wang and Jinrong Peng

    Citation: Cell Regeneration 2020 9:8

    Content type: Research

    Published on:

  18. Osteoarthritis (OA) has been defined as a chronic inflammatory joint disease characterized by progressive articular cartilage degeneration. Recently growing interest in regenerative medicine, using cell therap...

    Authors: Ghada Nour-Eldeen, Mazen Abdel-Rasheed, Amira M. EL-Rafei, Osama Azmy and Gehan T. El-Bassyouni

    Citation: Cell Regeneration 2020 9:7

    Content type: Research

    Published on:

  19. Given the limitations of current therapies for the reconstruction of bone defects, regenerative medicine has arisen as a new therapeutic strategy along with mesenchymal stem cells (MSCs), which, because of the...

    Authors: Maria Paula Benavides-Castellanos, Nathaly Garzón-Orjuela and Itali Linero

    Citation: Cell Regeneration 2020 9:5

    Content type: Research

    Published on:

  20. Transposable elements constitute about half of the mammalian genome, and can be divided into two classes: the class I (retrotransposons) and the class II (DNA transposons). A few hundred types of retrotranspos...

    Authors: Jingwen Wang, Junjiu Huang and Guang Shi

    Citation: Cell Regeneration 2020 9:4

    Content type: Review

    Published on:

  21. Chronic Traumatic Brain Injury (TBI) is one of the common causes of longterm disability worldwide. Cell transplantation has gained attention as a prospective therapeutic option for neurotraumatic disorders lik...

    Authors: Alok K. Sharma, Hemangi M. Sane, Pooja P. Kulkarni, Nandini Gokulchandran, Hema Biju and Prerna B. Badhe

    Citation: Cell Regeneration 2020 9:3

    Content type: Research

    Published on:

  22. We are using genetics to identify genes specifically involved in hearing regeneration. In a large-scale genetic screening, we identified mgat5a, a gene in the N-glycosylation biosynthesis pathway whose activity n...

    Authors: Wuhong Pei, Sunny C. Huang, Lisha Xu, Kade Pettie, María Laura Ceci, Mario Sánchez, Miguel L. Allende and Shawn M. Burgess

    Citation: Cell Regeneration 2016 5:3

    Content type: Research article

    Published on:

  23. Increasing evidence indicates that microRNAs (miRNAs), endogenous short non-coding RNAs 19–24 nucleotides in length, play key regulatory roles in various biological events at the post-transcriptional level. Em...

    Authors: Young Jin Lee, Suresh Ramakrishna, Himanshu Chauhan, Won Sun Park, Seok-Ho Hong and Kye-Seong Kim

    Citation: Cell Regeneration 2016 5:2

    Content type: Review

    Published on:

  24. Currently, direct conversion from somatic cells to neurons requires virus-mediated delivery of at least one transcriptional factor or a combination of several small-molecule compounds. Delivery of transcriptio...

    Authors: Songwei He, Yiping Guo, Yixin Zhang, Yuan Li, Chengqian Feng, Xiang Li, Lilong Lin, Lin Guo, Haitao Wang, Chunhua Liu, Yi Zheng, Chuanming Luo, Qiang Liu, Fuhui Wang, Hao Sun, Lining Liang…

    Citation: Cell Regeneration 2015 4:12

    Content type: Research article

    Published on:

  25. Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by the loss of motor neurons. Currently, no effective therapy is available to treat ALS, except for Riluzole, which has o...

    Authors: Zhijuan Mao, Suming Zhang and Hong Chen

    Citation: Cell Regeneration 2015 4:11

    Content type: Review

    Published on:

  26. Tissue-engineered constructs are promising to overcome shortage of organ donors and to reconstruct at least parts of injured or diseased tissues or organs. However, oxygen and nutrient supply are limiting fact...

    Authors: Karoline Pill, Sandra Hofmann, Heinz Redl and Wolfgang Holnthoner

    Citation: Cell Regeneration 2015 4:8

    Content type: Review

    Published on:

  27. Aging is considered an irreversible biological process and also a major risk factor for a spectrum of geriatric diseases. Advanced age-related decline in physiological functions, such as neurodegeneration, dev...

    Authors: Hoi-Hung Cheung, Duanqing Pei and Wai-Yee Chan

    Citation: Cell Regeneration 2015 4:6

    Content type: Review

    Published on:

  28. In the past decade, adipose tissue became a highly interesting source of adult stem cells for plastic surgery and regenerative medicine. The isolated stromal vascular fraction (SVF) is a heterogeneous cell pop...

    Authors: Eleni Oberbauer, Carolin Steffenhagen, Christoph Wurzer, Christian Gabriel, Heinz Redl and Susanne Wolbank

    Citation: Cell Regeneration 2015 4:7

    Content type: Methodology

    Published on:

  29. Hematopoiesis is a progressive process collectively controlled by an elaborate network of transcription factors (TFs). Among these TFs, GATA2 has been implicated to be critical for regulating multiple steps of...

    Authors: Ke Huang, Juan Du, Ning Ma, Jiajun Liu, Pengfei Wu, Xiaoya Dong, Minghui Meng, Wenqian Wang, Xin Chen, Xi Shi, Qianyu Chen, Zhongzhou Yang, Shubin Chen, Jian Zhang, Yuhang Li, Wei Li…

    Citation: Cell Regeneration 2015 4:4

    Content type: Research

    Published on:

  30. The ability to repair damaged or lost tissues varies significantly among vertebrates. The regenerative ability of the heart is clinically very relevant, because adult teleost fish and amphibians can regenerate...

    Authors: Gunes Ozhan and Gilbert Weidinger

    Citation: Cell Regeneration 2015 4:3

    Content type: Research

    Published on:

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