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Cell Regeneration
Fig. 3 | Cell Regeneration

Fig. 3

From: Capn3 depletion causes Chk1 and Wee1 accumulation and disrupts synchronization of cell cycle reentry during liver regeneration after partial hepatectomy

Fig. 3

Delayed hepatocyte proliferation in capn3bΔ19Δ14 at the resection site after PH. a, b Comparison of LBRs at 3-, 7- and 30-dpH in WT and capn3bΔ19Δ14 fish operated at the age of 8-months-old (a) or16-months-old (b). Sham control: cut through the abdominal skin only. c-f Co-staining of EdU and Bhmt (liver marker) at the wounding site of the liver in WT and capn3bΔ19Δ14 fish at 3dpH (c) and 7dpH (e). Red dashed line: outlining the cutting site. DAPI: staining nuclei. Scale bar: 50 μm. Corresponding statistical data of the EdU-positive cells were provided (d, 3dpH; f, 7dpH). EdU was injected 24 h before harvesting at 3dpH or 7dpH. Three sections per fish and total three fish were evaluated for each genotype in each case. Student’s T-test for statistical analyses, *, p < 0.05; **, p < 0.01

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