Intestinal epithelial plasticity and regeneration via cell dedifferentiation

Liu, Yuan; Chen, Ye-Guang

doi:10.1186/s13619-020-00053-5

Cell Regeneration

Table 1 The intestinal cells capable of self-renewal or de-differentiation

From: Intestinal epithelial plasticity and regeneration via cell dedifferentiation

Marker	Lineage	Overlapping expression	Tissue	Damage model	Mechanism	Reference
Bmi1	+4 reserve stem cells	Lgr5, Prox1, mTert, Krt19	Small Intestine	Irradiation, ablation of Lgr5+ through Lgr5-DTR mice	Unclear	(Lopez-Arribillaga et al. 2015; Sangiorgi and Capecchi 2008; Tian et al. 2011; Yan et al. 2012)
Bmi1	Enteroendocrine cells	Prox1	Small Intestine	Irradiation	Open chromatin	(Jadhav et al. 2017; Yan et al. 2017)
Hopx	+4 reserve stem cells	Lgr5, mTert, Krt19	Small Intestine	–	Unclear	(Takeda et al. 2011)
Hopx	Regenerative stem cells	ATOH1	Colon	DSS-induced colitis	Oxygen tension	(Wang et al. 2019)
Lrig1	Active ISCs	Lgr5	Small Intestine	–	Negative regulation of ErbB signaling	(Wong et al. 2012)
Lrig1	+4 reserve stem cells	Lgr5, Hopx, mTert, Krt19	Small intestine and colon	Irradiation	Negative regulation of ErbB signaling	(Powell et al. 2012)
Tert	+4 reserve stem cells	Lgr5, Bmi1, Mex3a	Small Intestine	Irradiation	Unclear	(Barriga et al. 2017; Breault et al. 2008; Montgomery et al. 2011)
Dclk1	+4 reserve stem cells	Msi1	Small Intestine	Irradiation	Unclear	(May et al. 2008; Nakanishi et al. 2013)
Dclk1	Tuft cells	–	Small intestine and colon	Irradiation, DSS-induced colitis	Unclear	(Gerbe et al. 2009; Westphalen et al. 2014)
LRCs^a	Secretory progenitors (short-term)	Lgr5, Hopx, Dll1, ATOH1, Sox9, Krt19	Small Intestine	Irradiation	Unclear	(Buczacki et al. 2013; Li et al. 2016; Roche et al. 2015)
LRCs^a	Paneth and Enteroendocrine -like cells (long-term)	Lyz1, c-Kit	Small Intestine	Irradiation	Unclear	(Li et al. 2016; Roche et al. 2015)
Dll1	Secretory progenitors	Sox9, ATOH1, Krt19	Small Intestine	Irradiation	Unclear	(van Es et al. 2012)
ATOH1	Secretory progenitors	Lgr5, Dll1, Hopx	Small intestine and colon	Irradiation, DSS-induced colitis	Multisite phosphorylation of ATOH1	(Ishibashi et al. 2018; Tomic et al. 2018)
Sox9	LRCs	Lgr5, Bmi1, Hopx, Lrig1, Dclk1, Dll1	Small Intestine	Irradiation	Unclear	(Roche et al. 2015)
Krt19	Upper crypts	Lgr5, Bmi1, Hopx, Lrig1, mTert, Dll1	Small intestine and colon	5-FU, ablation of Lgr5+ through Lgr5-DTR mice	Unclear	(Asfaha et al. 2015)
Lyz1	Paneth cell	c-Kit	Small Intestine	Irradiation, inflammation	SCF/c-Kit/Wnt pathway, forced activation of Notch pathway	(Schmitt et al. 2018; Yu et al. 2018)
Alpi	Enterocyte progenitor	–	Small Intestine	Ablation of Lgr5+ through Lgr5-DTR mice	Unclear	(Tetteh et al. 2016)
CD69, CD274	Goblet cell progenitor	–	Small Intestine	Ablation of Lgr5+ through Lgr5-DTR mice	Open chromatin	(Jadhav et al. 2017)
Prox1	Enteroendocrine cells, tuft cells	Bmi1	Small Intestine	Irradiation	Unclear	(Yan et al. 2017)
Mex3a	Quiescent stem cells	Lgr5	Small Intestine	5-FU, ionizing radiation	Unclear	(Barriga et al. 2017)
Ascl2	Enterocyte progenitor and secretory progenitor	Smoc2, Cdca7	Small intestine and colon	Ablation of Lgr5+ through Lgr5-DTR mice	Ascl2 to activate expression of its targets such as Il11ra1	(Murata et al. 2020)
Sca1	Repairing epithelium	Lrig1	Colon	DSS-induced colitis	Reprogram into fetal-like state by activation of YAP/TAZ pathway	(Yui et al. 2018)
Sca1	Progeny of ISCs	–	Small intestine	Infection by H.polygyrus, irradiation, ablation of Lgr5+ through Lgr5-DTR mice	IFN-γ-denpendent fetal-like transcriptional program	(Nusse et al. 2018)

^aLRCs Nucleotide analog label-retaining cells

Back to article page