Fig. 1
From: Proteins in DNA methylation and their role in neural stem cell proliferation and differentiation
Small molecules modulate NSCs by regulating TET1 activity. Vitamin C (Vc) increases the DNA demethylation activity of TET1 and increase both neurogenesis and astrogenesis of NSCs. Naloxone decreases the DNA demethylation activity of TET1, increases proliferation and neurogenesis of NSCs, and decreases astrogenesis