Fig. 4
From: The interaction of Notch and Wnt signaling pathways in vertebrate regeneration
The roles of Notch and Wnt signaling in zebrafish heart regeneration. During zebrafish heart regeneration, Notch signaling functions for CM proliferation and heart regeneration through a paracrine mechanism. After the amputation injury of zebrafish heart, Notch signaling is activated specifically in the endocardium and epicardium, but not in myocardial cells. Endocardial Notch signaling restrains myocardial Wnt pathway activation through inducing the expression of wif1 and notum1b, which encode two secreted Wnt antagonists, therefore promotes cardiomyocyte proliferation in the myocardium. The activated Notch signaling in epicardium may function in a similar manner to facilitate heart regeneration, which requires further exploration in the future