Table 1 most useful markers for the immunohistochemical identification of organ progenitors
From: Stem/progenitor cells in fetuses and newborns: overview of immunohistochemical markers
Subtypes of stem cells | Tissue | Stem cell markers |
|---|---|---|
Amniotic stem cells markers | Mesenchymal | CD105+; CD44+; CD73+; CD90+; CD29+; CD166+; CD13+; CD10+ (22); CD117+ (22) |
| Â | Epithelial | CD105-; NANOG+; CD133+; CD 271+; TRA-1-60+ |
| Â | Mesenchymal and epihelial | CD44+; CD73+; SOX2+; SOX3+; PAX6+; OCT3/4+; KLF4+; SSEA4+ |
| Â | Embryonal | SSEA3+ (22); SSEA5+ (22); TRA-1-60+ (8) (22); TRA-1-81+ (22) |
Umbilical cord stem cells markers | Mesenchimal | α-SMA+ (27); VCAM+ (27); CD44+ (29); CD73+ (29); CD105+ (29); CD90 (29); CD45- (29); CD34- (29); CD19- (29); HLA-DR- (29); CD11b - (29) |
| Â | Endothelial | CD34+ (31); CD133+ (31); VEGFR+ (31) |
Breast stem cells markers and breast milk stem cells markers | Breast stem cells | CD44+ (33); CD24- (33); ALDH1- (33) |
|  | Breast milk stem cells | Oct4+ (38); NANOG+ (38); CD49f+ (38); nestin+ (39) (41); ESRRB+ (40); CK5+ (40); CK14+ (40); α-lactalbumin+ (40); CD44+ (41) (42); CD29+ (41); Sca-1+ (41); vimentin+ (41); smooth muscle actin+ (41); Ki67+ (42) |
Thyroid stem cells markers | Human | CD44+; POU5F1+; nestin+; Oct- 4 +; GATA-4+; HNF4α+ |
| Â | Mouse and rat | VEGF-A+ (mouse); NANOG+ (rat); ABCG2+ (rat); GATA4+ (rat) |
Renal stem cells markers | Â | CD133+; CD24; CD44+; thymosin beta-4+; MUC-1+; CD10+; WT1+ |
Cardiac stem cells markers | Â | Sca-1+; CD31+; CD38+; GATA-4+; MEF 2C+; TEF-1+; WT1+; Wnt1+; CD44+; ISL1+ (70); c-kit- (64); CD34- (64); CD45- (64) |
Pulmonary stem cells markers | Â | TTF1+ (73) |
| Â | Epithelial precursors | SOX2+ |
| Â | Mesenchyme | WT1+ |
Cutaneous stem cells markers | Melanocytes | CD20+; CD133+ |
| Â | Hair follicles | CK15+; nestin+ |
Pancreatic stem cells markers | Â | PDX1+; Ptf1-alpha+; SOX9 + |
Adrenal stem cells markers | Â | NCAM+; CD117+; NSE+; PDGFr-alpha+; Synaptophysin+; Hepatocyte growth factor+; alpha-feto-protein+; Pbx1+; SF1+ |
Intestinal stem cells markers | Â | Lgr5+; Wnt+; BMP+; Notch+; EGF+; p-TEN+; p-AKT+; Fgfr3+; CD44 + |
| Â | Paneth cells | CD24+ |
Liver stem cells markers | Biliary progenitor | CK19+; CK7+ |
| Â | Multipotent undifferentiated hepatic stem/progenitors | NCAm+; CD133+; SOX9+; SOX17+; FOXA2+; Ck 8/18+ |
| Â | Hepatoblasts | albumin+; CYPA4+; CYPA7+ |
|  | Committed hepatic progenitors | albumin+; glucose-6-phosphate+; CK19+; α-fetoprotein+ |
Brain stem cells markers | Primary neuroepithelium | Nestin+ |
| Â | Radial glia | Nestin+; vimentin+; WT1+ |
| Â | Brain stem cells | SOX2 (103) |
Endometrial stem cells | Â | CD44+; CD90+; CD105+; OCT4+; c-KIT (CD117)+; CD34+; bcl2+; CD146+; PDGF-Rbeta+; ISL1 |