Fig. 2

Intravenous Administration of ceAF Improved Cardiac Function in a Mouse Model of Heart Ischemic Reperfusion. Mice with heart IR were treated with ceAF of different doses (1.5 ml, 5 ml, and 10 ml/kg) and LCZ696 (60 mg/kg) as positive control. The LVEF (a), FS (b), HW/BW (c), ESD (d), ESV (e), SBP (f), LVSP (g), and LVEDP (h) of these mice were improved after 28-day ceAF treatment. i Representative images of Sirius red staining on heart tissue sections. Bar, 2 mm. j Percentage of fibrosis evaluated according to the Sirius red staining. Data are shown as mean ± SEM. (n = 10, ns, no significance, *p < 0.05, **p < 0.01, ***p < 0.001, and ****p < 0.0001 by one-way ANOVA adjusted by Brown-Forsythe test)