Table 1 Summary of the specific markers of intestinal epithelial cells
From: Intestinal cellular heterogeneity and disease development revealed by single-cell technology
Cell types | Marker genes | |
|---|---|---|
Mouse intestine | Human intestine | |
Enterocyte | Alpi, Fabp1, Slc26a3 (Apoa1 in SI *) | ALPI, FABP1, SLC26A3 (APOA1 in SI *) |
Goblet cell | Muc2, Spdef, Clca1, Zg16, Spink4, Fcgbp | MUC2, SPDEF, CLCA1, ZG16, SPINK4, FCGBP |
Enteroendocrine cell | Neurog3, Neurod1, Chga, Chgb | NEUROG3, NEUROD1, CHGA, CHGB |
Paneth cell | Lyz1, Defa5, Defa6 | LYZ, DEFA5, DEFA6 |
Tuft cell | Dclk1, Pou2f3, Trpm5, Il25 | POU2F3, TRPM5, IL25 |
TA cell (Lgr5-negative) | Mki67, Hmgb2, Top2a, Ube2c, Stmn1 | MKI67, HMGB2, TOP2A, UBE2C, STMN1 |
Stem cell | Lgr5, Ascl2, Rgmb, Smoc2, (Olfm4 in SI *) | LGR5, ASCL2, RGMB, SMOC2, (OLFM4 in SI *) |
BEST4 cell | Absent in mice | BEST4, SPIB, CA7, OTOP2 |
 + 4 stem cell | Bmi1, Hopx, Tret, Lrig1, Mex3a | Need to be confirmed |