Zebrafish: a convenient tool for myelopoiesis research

Cell Regeneration

Table 1 Important transcription factors in myelopoiesis and myeloid disorders

Transcription factor	Family	Genetic manipulation	Hematopoietic phenotype	Reference
pu.1	ETS	Knockout	Immature granulocytes	(Sun et al. 2013)
spi-b	ETS	Knockdown	Decreased neutrophils and macrophages	(Bukrinsky et al. 2009)
runx1	Runt	Knockout	Immature neutrophils	(Huang et al. 2021)
C/EBPα	Runt	Knockout	Decreased macrophages and neutrophils	(Dai et al. 2016; Hockings et al. 2018)
C/EBPβ	Runt	Knockdown	Suppressed emergency granulopoiesis	(Hall et al. 2012)
C/EBPδ	Runt	Knockdown	Increased myeloid differentiation	(Tregnago et al. 2016)
irf8	IRF	Knockout	Impaired macrophage specification and longevity	(Tamura et al. 2005)
gata1	GATA	Knockout	Reduced eosinophils, morphologically abnormal mast cells, impaired dendritic-cell differentiation	(Gutiérrez et al. 2007; Migliaccio et al. 2003; Yu et al. 2002)
gata2a	GATA	Knockout	Reduced primitive monocyte/macrophages	(Peña et al. 2021)
gata2b	GATA	Knockout	Reduced definitive HSPCs and neutrophils	(Gioacchino et al. 2021; Peña et al. 2021)
gata4/5/6	GATA	Knockdown	Reduced definitive granulocytes and macrophages	(Jia et al. 2019)
SOX4	HMG	Overexpression	Enhance MPC proliferation	(Sandoval et al. 2012)
pax9	Pax	Knockout	Reduced neutrophils	(Pak et al. 2021)
scl	HLH	Knockdown	Impaired monocytes and macrophages	(Dooley et al. 2005)
lmo2	LIM	Knockdown	Reduced granulocytes and macrophages	(Patterson et al. 2007)
c-myb	Myb	Knockout	Immature neutrophils	(Jin et al. 2016)