Fig. 3

PHDs-seq screen to discover candidate drugs that promote adipocyte reprogramming. A Schematic diagram of steps in the PHDs-seq screening process. B Schematic for the calculation of signature index (SI). C Radar map of the adipocyte SI for top30 samples. Sample names are compound names. D Hierarchical clustering of PHDs-seq data from 128 compounds and control treatments. Blue indicates negative control KF samples or ineffective compounds; red indicates AD positive controls or candidates; _1 and _2 represent biological replicates. E Pearson correlation analysis of candidates, AD, and KF data from PHDs-seq. F PCA analysis of PHDs-seq data from 128 compounds and control treatments. G PCA analysis of the major contributing genes