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Cell Regeneration
Fig. 4 | Cell Regeneration

Fig. 4

From: PHDs-seq: a large-scale phenotypic screening method for drug discovery through parallel multi-readout quantification

Fig. 4

Lanifibranor and ABT869 promote adipocyte reprogramming. A Quantification of adipocyte induction in presence of Rosi or Lani in AD medium minus Rosi; **** p < 0.0001, *** p < 0.001, ns, p > 0.05 between the indicated groups, biologocal replicates: 2, numbers in square brackets indicate concentration in μM. B Reprogrammed adipocyte morphology of cells in (A). C Adipocyte reprogramming dose response curve for ABT869 in AD medium minus Rosi, biologocal replicates: 3, **** p < 0.0001, ns, p > 0.05 between indicated groups. D Nile red staining for lipid in adipocytes (red) or Hoechst (blue). ABT: ABT869; concentration: 2 μM; scale bar = 100 μm; HG, DMEM/high glucose medium. E Statistical analysis of adipocyte percentages per field in (D), fields: 4, **** p < 0.0001, * p < 0.05 between indicated groups. F qPCR quantification of the indicated adipocyte marker expression levels. biologocal replicates: 3, **** p < 0.0001, * p < 0.05 between indicated groups. Statistical methods: One-way Analysis of Variance (ANOVA) in (A)(C)(E)(F)

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